664333-44-2

Usage

Uses

There is no specific information provided about the uses of 2,4(1H,3H)-Pyrimidinedione, 1-[(4R,5R,7R,8R)-7-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-8-[[((1,1-dimethylethyl)dimethylsilyl)oxy]-1,6-dioxaspiro[3.4]oct-5-yl]-5-methylin the provided materials. However, given its complex structure and potential pharmacological effects, it may have applications in various industries, such as pharmaceuticals, agrochemicals, or materials science, depending on its specific properties and interactions with biological targets. Further research and development would be required to determine its practical applications and benefits.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 664333-42-0 1-[3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-2-C-(2-hydroxyethyl)-β-D-ribofuranosyl]thymine 
• 664333-36-2 1-[2-C-allyl-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]thymine 
• 666723-04-2 1-(2-C-allyl-β-D-ribofuranosyl)thymine 
• 157037-56-4 1,3,5-tri-O-benzoyl-2-oxo-α-D-erythro-pentofuranose 
• 664333-43-1 1-[3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-2-C-(2-methanesulfonyloxyethyl)-β-D-ribofuranosyl]thymine 
• 664333-35-1 1-[2-C-allyl-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]thymine 
• 666723-03-1 1,2,3,5-tetra-O-benzoyl-2-C-allyl-D-ribofuranose 

Downstream Products

• 664333-45-3 1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-ethano-β-D-ribofuranosyl]thymine 

Relevant academic research and scientific papers

2′-Spiro ribo- and arabinonucleosides: Synthesis, molecular modelling and incorporation into oligodeoxynucleotides

We have synthesized four conformationally restricted bicyclic 2′-spiro nucleosides via 2′-C-allyl nucleosides as key intermediates. The ribo-configured 2′-spironucleosides 9b and 14b were obtained by a convergent strategy starting from 2-ketofuranose 1 whereas the arabino-configured 2′-spironucleosides 21 and 27 were obtained by a linear strategy with a 2′-ketouridine derivative as starting material. The furanose ring of 9b/14b adopts N-type conformations whereas the furanose ring of 21/27 exists as an N?S equilibrium. These compounds snowed no anti-HIV-1 activity or cytotoxicity. Incorporation of the four 2′-spironucleosides (as monomers X4 and X5) into oligodeoxynucleotides was accomplished using the phosphoramidite approach on an automated DNA synthesizer. Irrespective of monomeric configuration, hybridization studies revealed that these 2′-spironucleotide monomers (X4 and X5) induce decreased duplex thermostabilities compared with the corresponding DNA:DNA and DNA:RNA duplexes. Molecular modelling indicated that steric constraints are a possible reason for the lowered binding affinities of the modified oligodeoxynucleotides towards complementary single-stranded DNA and single-stranded RNA complements.