664366-05-6

Usage

Uses

Used in Pharmaceutical Industry:
(3-tert-Butyl-5-methyl-7-oxo-7H-furo[3,2-g]-chromen-6-yl)acetic acid is used as a potential therapeutic agent for its anti-inflammatory, anti-cancer, and antioxidant properties. It may be employed in the development of drugs targeting various diseases and conditions.
Used in Dermatology:
(3-tert-Butyl-5-methyl-7-oxo-7H-furo[3,2-g]-chromen-6-yl)acetic acid is used as a potential treatment for skin disorders due to its pharmacological properties. It may help in managing skin conditions by reducing inflammation and promoting healing.
Used in Photodynamic Therapy:
(3-tert-Butyl-5-methyl-7-oxo-7H-furo[3,2-g]-chromen-6-yl)acetic acid is used as a potential photosensitizer in photodynamic therapy. It may be utilized in the treatment of certain types of cancer and other conditions by enhancing the effects of light therapy.
Further research is needed to fully understand the biological activities and potential uses of (3-tert-Butyl-5-methyl-7-oxo-7H-furo[3,2-g]-chromen-6-yl)acetic acid in medicine.

Upstream product

• 13547-70-1 1-chloro-3,3-dimethyl-butan-2-one 
• 1115-30-6 diethyl acetylsuccinate 
• 108-46-3 recorcinol 
• 5852-03-9 ethyl 2-(7-hydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetate 
• 10420-33-4 dimethyl 2-acetylsuccinate 
• 95903-37-0 7-hydroxy-3-methoxycarbonylmethyl-4-methyl-2H-chromen-2-one 
• 664365-85-9 methyl [4-methyl-7-(3',3'-dimethyl-2'-oxobutoxy)-2-oxo-2H-benzopyran-3-yl]-acetate 

Relevant academic research and scientific papers

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

Elevated expression of the immunoproteasome has been associated with autoimmune diseases, inflammatory diseases, and various types of cancer. Selective inhibitors of the immunoproteasome are not only scarce, but also almost entirely restricted to peptide-based compounds. Herein, we describe nonpeptidic reversible inhibitors that selectively block the chymotrypsin-like (β5i) subunit of the human immunoproteasome in the low micromolar range. The most potent of the reversibly acting compounds were then converted into covalent, irreversible, nonpeptidic inhibitors that retained selectivity for the β5i subunit. In addition, these inhibitors discriminate between the immunoproteasome and the constitutive proteasome in cell-based assays. Along with their lack of cytotoxicity, these data point to these nonpeptidic compounds being suitable for further investigation as β5i-selective probes for possible application in noncancer diseases related to the immunoproteasome.

Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: Design, synthesis and biological effects

Nuclear Factor kappaB (NF-κB) plays a very important role in the control of gene expression and is deeply involved in several human pathologies. Accordingly, molecules targeting NF-κB dependent biological functions are considered of great interest. Virtua

Modified coumarins. 10. Synthesis of substituted 2-(7-oxofuro[3,2-g] chromen-6-yl) acetic acids

Substituted 2-(7-oxofuro[3,2-g]chromen-6-yl) acetic acids, modified psoralen analogs, were synthesized by linear fusion of a furan ring to the coumarin system.