66444-36-8

Upstream product

• 111934-10-2 (S)-2-[(S)-2-(2-Aza-bicyclo[2.2.1]hept-5-en-2-yl)-3-phenyl-propionylamino]-4-methyl-pentanoic acid methyl ester 
• 38155-45-2 methyl L-phenylalanyl-L-leucinate hydrochloride 

Downstream Products

• 112550-45-5 N-(tert-butyloxycarbonyl)-glycyl-N-methyl-L-phenyl-alanyl-L-leucine methyl ester 
• 112550-46-6 (S)-2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid 

Relevant academic research and scientific papers

Immonium Ion Based Synthetic Methodology: A Novel Method for the N-Methylation of Dipeptides and Amino Acid Derivatives via Retro Aza Diels-Alder Reactions

A novel method for the N-methylation of amino acid derivatives and dipeptides is detailed that features facile room-temperature retro Diels-Alder reactions of N-substituted 2-azanorbornenes with trapping of the incipient immonium ion with triethylsilane/trifluoroacetic acid.