66446-96-6

Basic information

• Product Name: 2-Heptanone, 1-iodo-
• CAS NO: 66446-96-6
• Molecular Formula: C7H13IO
• Molecular Weight: 240.084
• Mol File: 66446-96-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Heptanone, 1-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Heptanone, 1-iodo-(66446-96-6)
• EPA Substance Registry System: 2-Heptanone, 1-iodo-(66446-96-6)

Safety Data

• Hazardous Substances Data: 66446-96-6(Hazardous Substances Data)

Usage

General Description

2-Heptanone, 1-iodo- is a chemical compound that is also known as iodine heptanone. It is a halogenated ketone with the formula C7H13IO. 2-Heptanone, 1-iodo- is commonly used as an intermediate in organic synthesis, especially in the preparation of pharmaceuticals and agrochemicals. It has a strong, pungent odor and is considered to be a moderately hazardous chemical. 2-Heptanone, 1-iodo- is also used in research as a building block for the synthesis of more complex organic molecules. It is important to handle this compound with care and to follow proper safety protocols when working with it.

Upstream product

• 110-43-0 n-pentyl methyl ketone 
• 19980-27-9 (Z)-<(trimethylsilyl)oxy>-2-heptene 

Downstream Products

• 208348-93-0 2-hydroxy-nonan-4-one 
• 80519-91-1 2-oxoheptyl-p-ethoxybenzenesulfonate 
• 110-43-0 n-pentyl methyl ketone 
• 17046-01-4 1-hydroxypentan-2-one 

Relevant articles and documents

Visible-Light-Triggered Iodinations Facilitated by Weak Electrostatic Interaction of N-Heterocyclic Carbenes

N-heterocyclic carbenes (NHCs) are well-known as ligands and organocatalysts, but there is no recognition for their catalytic role as a stabilizer through electrostatic interaction rather than electron donation. By utilizing the electrostatic interaction, we herein describe the success of a visible-light-triggered radical-radical cross-coupling of N-alkenoxypyridinium salts and NaI, giving a variety of α-iodo ketones. Computational studies characterize the stabilization role of NHCs.

A New α-Iodination of Ketones Using Iodine-Ammonium Cerium(IV) Nitrate in Alcohol or Acetic Acid

The direct α-iodination of various ketones using iodine-ammonium cerium(IV) nitrate in acetic acid or alcohol gave the corresponding α-iodo ketones in high yields. The effect of cerium salt on the iodination of ketones, and the iodination of 5α-cholestan-3-one using several methods are also discussed. In the reaction of 3,3,5-trimethylcyclohexanone and unsymmetrical ketones, such as 2-hexanone and 2-heptanone, using methanol, ethanol, 1-propanol, and 2-propanol, the regioselective iodination product was obtained. In the case of bromination, the reaction of ketones with bromine and ammonium cerium(IV) nitrate also yielded the corresponding α-bromo ketones.

Synthesis of α-Iodo Ketones

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