66449-93-2

Upstream product

• 21715-90-2 N-hydroxy-5-norbornene-2,3-dicarboximide 
• 2389-45-9 Boc-Lys(Z)-OH 

Downstream Products

• 79701-06-7 (R)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-pentanedioic acid dimethyl ester 
• 79700-97-3 (R)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-carbamoyl-butyric acid methyl ester 
• 82254-65-7 (S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester 
• 32769-96-3 Boc-Lys(Z)-Lys(Z)-OBzl 
• 79701-05-6 [(S)-5-tert-Butoxycarbonylamino-5-((R)-1,3-dicarbamoyl-propylcarbamoyl)-pentyl]-carbamic acid benzyl ester 
• 66111-56-6 (R)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-carbamoyl-butyric acid benzyl ester 

Relevant academic research and scientific papers

Application of a unique automated synthesis system for solution-phase peptide synthesis

An automated synthesis system, which is suitable for repetitive syntheses using similar reaction procedures, was used to synthesize systematically a library of all possible dipeptides (25) and tripeptides (125) from 5 protected amino acids. The apparatus has also been applied to the automated synthesis of 10 fragment tripeptide derivatives that are constituents of the hormone PACAP-27. The measured molecular optical rotation values of the library of 125 tripeptides were found to correlate well with calculated values obtained by summation of the molecular optical rotation values for the constituent amino acids.