6647-98-9

Usage

Uses

Used in Pharmaceutical Research and Development:
4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID is used as a key building block for the synthesis of new pharmaceutical compounds, leveraging its unique structure and reactivity to create novel drug candidates with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID is employed as a versatile reagent, contributing to the creation of a wide range of organic molecules for various applications, including but not limited to materials science, agrochemicals, and specialty chemicals.
Used in Chemical Reactions:
4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID is utilized as a reagent in various chemical reactions, taking advantage of its iodo and methyl groups to facilitate specific transformations and provide access to a diverse array of chemical products.
Used in Research and Development:
4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID is also used in research and development settings to explore its potential applications and to understand its chemical behavior, which can lead to the discovery of new uses and properties that can be harnessed in different industries.

Upstream product

• 6647-97-8 4-iodine-1,3-dimethyl-1H-pyrazole 
• 25016-20-0 1-methylpyrazole-3-carboxylic acid 
• 179692-08-1 4-iodo-1H-pyrazole-3-carboxylic acid ethyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 93703-07-2 1-Methyl-4-p-tolylamino-1H-pyrazole-3-carboxylic acid 
• 93703-08-3 4-(4-Methoxy-phenylamino)-1-methyl-1H-pyrazole-3-carboxylic acid 
• 93703-06-1 1-Methyl-4-phenylamino-1H-pyrazole-3-carboxylic acid 
• 4598-86-1 1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

HALO-SUBSTITUTED PIPERIDINES AS OREXIN RECEPTOR MODULATORS

The present application relates to certain halo-substituted piperidine compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.

New approach to electrochemical iodination of arenes exemplified by the synthesis of 4-iodopyrazoles of different structures

The two-stage electrosynthesis of 4-iodosubstituted pyrazole derivatives was performed. At the first stage, KIO3 was obtained at the Ni anode under the undivided galvanostatic conditions of electrolysis of an aqueous alkaline solution of KI (or I2) at the Ni anode. At the second stage, pyrazole and its derivatives were iodinated in the heterophase (H2O-CHCl3 (CCl4)) medium by the KIO3-KI (or KIO3-I2) system in the presence of H2SO4. The yields of iodopyrazoles were 74-92%. The electrochemical iodination of anisole, 2-methylpyrazole, and thiophene was carried out to form 4-iodoanisole (88% yield), 4,5-diiodo-2-methylimidazole (54% yield), and a mixture of 2-iodothiophene (60% yield) and 2,5-diiodothiophene (4% yield).

Efficient iodination of structurally varying pyrazoles in heterophase medium

A synthesis of 4-iodo-substituted pyrazoles by iodination of pyrazole and its derivatives in the heterophase (H2O/CHCl3 (CCl 4)) medium with the system KI-KIO3 in the presence of H2SO4 additives was accomplished. The yields of 4-iodo-substituted pyrazoles in the iodination of pyrazole, 3,5- dimethylpyrazole, pyrazole-3(5)-carboxylic acid, 1-methylpyrazole-3-carboxylic acid, 1-methylpyrazole-5-carboxylic acid, 3-nitropyrazole, 1-methyl-3- nitropyrazole, 1-methylpyrazole, 1-ethylpyrazole, and 1-isopropylpyrazole were within 80-97%, whereas in the case of 3-nitropyrazole-5-carboxylic acid it was 32%.