66498-51-9

Upstream product

• 622-76-4 1-phenyl-1-butyne 

Downstream Products

• 78844-14-1 ((2S,3R)-2-Ethyl-3-phenethyl-oxiranyl)-phenyl-methanone 
• 136454-43-8 2,2-Dimethyl-propionic acid (Z)-2-bromo-1-phenyl-but-1-enyl ester 
• 59875-94-4 1,1-dibenzoylpropane 
• 109037-01-6 2-ethyl-1,3-diphenyl-propenone 
• 78844-13-0 trans-2,3-epoxy-2-ethyl-1,3-diphenyl-1-propanone 
• 136454-45-0 4-Methyl-benzoic acid (Z)-2-bromo-1-phenyl-but-1-enyl ester 
• 20577-41-7 (E,Z)-2-Ethyl-1-phenyl-2-buten-1-on 
• 34581-52-7 2-ethyl-1-phenyl-1,3-hexanedione 
• 151390-49-7 (Z)/(E)-2-Brom-1-phenyl-1-(trimethylsiloxy)-1-buten 

Relevant academic research and scientific papers

CoFe2O4–SiO2–SO3H nanocomposite as a magnetically recoverable catalyst for oxidative bromination of alkynes

A hybrid catalyst has been prepared by incorporating sulfonic acid onto cobalt ferrite magnetic nanoparticles. The catalyst was successfully applied for rapid (20 min) synthesis of α,α-dibromoketones directly from alkynes and NBS. The reaction works well in the presence of 10 wt% of the catalyst at room temperature to produce the desired products in high yield. The catalyst could be recovered using an external magnet and reused without appreciable change in activity.

TsNBr2mediated oxidative functionalization of alkynes

A new approach has been developed for oxidative transformation of alkynes by controlled manipulation of TsNBr2mediated process. Alkynes could be readily converted to ketones and α-bromoketones via an oxybromination–debromination sequence. When alkynes are treated successively with TsNBr2, KI and Na2SO3in a mixture of acetone and water at room temperature, corresponding ketones were obtained. On the other hand, treatment of alkynes with TsNBr2and Na2SO3in a mixture of ethyl acetate, acetone and water at room temperature could produce corresponding α-bromoketones. 1-Bromoalkynes could also be synthesized from corresponding alkynes within a very short time using TsNBr2at room temperature. In all cases, excellent yields of corresponding products are obtained.

K 2S 2O 8-mediated difunctionalization of C≡C bonds in water: A simple and efficient approach to α, α -dihaloacetophenones from phenylacetylenes and NaX

A novel K2S2O8-mediated oxy-1,1-dihalogenation of alkynes with NaX in the presence of water has been developed, affording α,α-dihaloacetophenones in moderate to good yields. The advantages of this reaction are mild reaction conditions, operational simplicity, and use of pure water as reaction medium. A plausible reaction mechanism is proposed on the basis of mechanistic studies.

Selective 1,2-dihalogenation and oxy-1,1-dihalogenation of alkynes by N-halosuccinimides

1,2-Dihalogenation and oxy-1,1-dihalogenation of alkynes by N-halosuccinimides can be selectively realized through using different reaction conditions. α,β-Dihalo alkenes were obtained exclusively using THF as solvent without using any catalyst, while α,α