664986-03-2

Upstream product

• 98-10-2 benzenesulfonamide 
• 106-43-4 para-chlorotoluene 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 907563-71-7 N-[(3E)-2,2-dichloro-1-(4-chlorophenyl)-3-(cyclohexylimino)-3-phenylpropyl]phenylsulfonamide 
• 907563-70-6 N-[(3E)-2,2-dichloro-1-(4-chlorophenyl)-3-(isopropylimino)-3-phenylpropyl]phenylsulfonamide 

Relevant academic research and scientific papers

Solvent-free synthesis of N-sulfonyl imines using WCl6 as a novel, highly efficient and reusable catalyst

WCl6 was used as a novel, efficient and reusable catalyst for the preparation of N-sulfonyl imines via the condensation of sulfonamides with aldehydes as well as isatin under solvent-free conditions. The turn-over frequency (TOF) value of the c

Oxidative imination of toluenes catalyzed by Pd-Au/silica gel under mild reaction conditions

A Pd-Au/SiO2 catalyst was prepared for the oxidative imination of toluenes with up to 99% yields in the absence of dehydrating agents under mild conditions. Nanoparticles with a PdO layer and PdO-Au core may be the active structure for the reaction.

Cyanuric chloride-catalyzed synthesis of N-sulfonyl imines

Cyanuric chloride is an inexpensive, efficient, and mild catalyst for the synthesis of N-sulfonyl imines by the reaction of sulfonamides with aryl aldehydes at 110°C under solvent-free conditions. This method affords the N-sulfonyl imines in short reactio

Green, Catalyst-Free Protocol for the Efficient Synthesis of N-Sulfonyl Aldimines and Ketimines in Ionic Liquid [Bmim]Br

Sulfonamides are efficiently condensed with aldehydes as well as ketones in the absence of catalyst in 1-butyl-3-methylimidazolium bromide ([bmim]Br) under microwave irradiation to afford N-sulfonyl aldimines and ketimines in good to excellent yields in s

Triarylmethyl chlorides as novel, efficient, and mild organic catalysts for the synthesis of N-sulfonyl imines under neutral conditions

A highly efficient procedure for the preparation of N-sulfonyl imines via condensation of sulfonamides with aldehydes as well as ketones in the presence of triarylmethyl chlorides as metal-free organo-catalysts at 40 °C is described. The advantages of thi

Small-molecule inhibitors of protein geranylgeranyltransferase type I

Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To further improve the efficacy of the GGTase-I inhibitors (GGTIs), 4288 related compounds bearing core dihydropyrrole/pyrrolidine and tetrahydropyridine/piperidine scaffolds were synthesized on SynPhase lanterns in a split-pool manner through phosphine-catalyzed [3 + 2] and [4 + 2] annulations of resin-bound allenoates. Testing of the 4288 analogues resulted in several GGTIs exhibiting submicromolar IC50 values. Because proteins such as Ras and Rho GTPases are implicated in oncogenesis and metastasis, these GGTIs might ultimately lead to the development of novel antitumor therapeutics. Copyright

Synthesis of 2-chloro-2-imidoylaziridines via aza-darzens-type reaction of 3,3-dichloro-1-azaallylic anions and N-(arylsulfonyl)imines

3,3-Dichloro-1-azaallylic anions, generated by deprotonation of α,α-dichloroketimines 10 with lithium diisopropylamide, reacted with N-sulfonylaldimines 7 to produce the Mannich-type products N-[2,2-dichloro-3- (N-alkylimino)-1,3-diarylpropyl]benzenesulfo

An efficient and convenient procedure for preparation of N-sulfonylimines catalysed by TiO2/SO42- solid superacid

A facile synthesis of N-sulfonylimines in good to excellent yields was described from aldehydes with sulfonamides catalysed by TiO2/SO 42- solid superacid.