66522-71-2Relevant academic research and scientific papers
Substituted pyrimidinetrione compound, composition containing same and application of substituted pyrimidinetrione compound
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Paragraph 0089; 0092-0094, (2018/11/22)
The invention provides a substituted pyrimidinetrione compound, a composition containing the same and application of the substituted pyrimidinetrione compound. The invention discloses the pyrimidinetrione compound as shown in formula (I) or the crystal form, pharmaceutically acceptable salt, prodrug, stereisomer, hydrate or solvent compound thereof. The pyrimidinetrione compound and the composition containing the same can be used for regulating hypoxia-inducible factors (HIF) and/or erythropoietin (EPO) and can be used for preparing medicine for regulating and controlling human body anemia.
A kind of an isotope-labeled sodium cyclamate and its preparation method
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Paragraph 0031, (2017/03/21)
The invention discloses isotope labeled sodium cyclamate and a preparation method thereof. The sodium cyclamate is sodium cyclamate labeled by isotopic deuterium. The chemical structural formula is as follows, wherein X is H or D. The preparation method of the sodium cyclamate comprises the following steps: by taking cyclohexanone as a raw material, firstly, carrying out H-D exchange on heavy water and cyclohexanone to obtain tetradeuterated cyclohexanone; then, reducing and ammoniating to obtain tetradeuterated cyclohexylamine or pentadeuterated cyclohexylamine; and then sulfonating and alkalizing to obtain sodium cyclamate. The isotope abundance of the isotope labeled sodium cyclamate reaches over 99% which fully meets the demands of detection reagents. The method is simple in synthetic process and cheap in price of raw material and the synthesized product has the advantages of high product purity, low production cost and the like, and is easy to separate and purify. The isotope labeled sodium cyclamate has good economical efficiency and using value.
The Formation of Enaminoenaminones from N-Alkylaminomethylene Derivatives of Meldrum's Acid
Gordon, Helen J.,Martin, Jane C.,McNab, Hamish
, p. 2129 - 2132 (2007/10/02)
Gas-phase pyrolysis of aminomethylene derivatives of Meldrum's acid gives enaminoenaminones .Deuterium labelling stidies have shown that the mechanism involves tautomerism of the initial methyleneketene intermediate to an iminoketene,
