66534-53-0Relevant academic research and scientific papers
Arene-catalysed lithiation of phenyl- and 1,1-diphenylcyclopropane: synthetic applications
Gómez, Cecilia,Lillo, Victor J.,Yus, Miguel
, p. 4655 - 4662 (2007/10/03)
The reaction of phenylcyclopropane (1) with an excess of lithium and a catalytic amount of DTBB (2.5% molar) in THF at room temperature, followed by treatment with an electrophile [Me3SiCl, PhMe2SiCl, t-BuCHO, PhCHO, Me2CO
Pd-catalyzed nucleophilic allylic alkylation of aliphatic aldehydes by the use of allyl alcohols
Kimura, Masanari,Shimizu, Masamichi,Tanaka, Shuji,Tamaru, Yoshinao
, p. 3709 - 3718 (2007/10/03)
Under catalysis of Pd(OAc)2-(P-n-Bu)3, Et 2Zn promotes a variety of allyl alcohols to undergo nucleophilic allylation of aliphatic aldehydes and ketones at room temperature and provides homoallyl alcohols in 60-90 and ca. 60% isolated yield, respectively. The reaction is irreversible and kinetically controlled, and unique regio- and stereoselectivities observed for the allylation with unsymmetrically substituted allyl alcohols are discussed.
