66541-11-5

Upstream product

• 87899-09-0 1-(3-Ethyl-4,5-dihydro-isoxazol-5-yl)-hexan-1-one 
• 932-90-1 Benzaldoxime 
• 1186-47-6 1,1-dihydroxyacetone 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 87899-18-1 2-phenyl-4,5-dihydroxy-5-methyl-1-pyrroline 
• 101028-24-4 trans-2,3-Epoxy-1-phenyl-1,4-pentanedione 

Downstream Products

• 86905-46-6 2-Methyl-5-phenyl-furan-3-one 

Relevant academic research and scientific papers

Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water

An environmentally benign decarboxylative aldol reaction of β-ketoacids with glyoxylate and glyoxal monohydrates in water is reported. The reaction proceeds smoothly without any base and metal catalysts, affording the corresponding β-hydroxy ketones in high yields. A preliminary mechanism study of this aldol transformation suggests a stepwise process involving the nucleophilic addition of β-ketoacids to glyoxylate hydrates and glyoxal monohydrates followed by a subsequent decarboxylation reaction.

Reductive ring-opening reaction of 2,3-epoxy-1,4-butanediones with SbCl3-Bu4NI in the presence of Na2S 2O3·5H2O

1,4-Disubstituted 2,3-epoxy-1,4-butanediones were converted to 1,4-disubstituted 2-hydroxy-1,4-butanediones with SbCl3-Bu 4NI in the presence of Na2S2O 3-5H2O. The ring opening of terminal epoxides can also be accomplished to afford the corresponding haloalcohol with SbCl3 and tetrabutylammonium halides, Bu4NX (X = Cl, Br, I) under the same reaction conditions. Copyright Taylor & Francis, Inc.

SILYL NITRONATES IN ORGANIC SYNTHESIS. SYNTHESIS OF 3(2H)-FURANONES

A synthesis of 3(2H)-furanones, a structural element of several natural products, has been developed in which silyl nitronates or nitrile oxides are condensed with vinyl ketones to form 5-acyl-2-isoxazolines which are reduced with titanous ions or catalytically to 1,4-diketo-2-ols and cyclized with sodium acetate in acetic acid.