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66542-37-8

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66542-37-8 Usage

General Description

(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate is a chemical compound with the molecular formula C9H11FN2O4. It is a derivative of the pyrimidine compound and is commonly used in the synthesis of pharmaceuticals. (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate has potential applications in the development of antiviral and antitumor drugs due to its ability to inhibit the growth of certain types of cancer cells and viruses. Additionally, it has been studied for its potential use in the treatment of neurological disorders and as an antibacterial agent. The chemical structure of (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate makes it a versatile building block for the synthesis of new compounds with potential therapeutic properties.

Check Digit Verification of cas no

The CAS Registry Mumber 66542-37-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,4 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66542-37:
(7*6)+(6*6)+(5*5)+(4*4)+(3*2)+(2*3)+(1*7)=138
138 % 10 = 8
So 66542-37-8 is a valid CAS Registry Number.

66542-37-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (5-fluoro-2,4-dioxopyrimidin-1-yl)methyl butanoate

1.2 Other means of identification

Product number -
Other names 1-butyryloxymethyl-5-fluoro-1H-pyrimidine-2,4-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66542-37-8 SDS

66542-37-8Downstream Products

66542-37-8Relevant articles and documents

1-Alkylcarbonyloxymethyl prodrugs of 5-fluorouracil (5-FU): Synthesis, physicochemical properties, and topical delivery of 5-FU

Taylor, H. Elizabeth,Sloan, Kenneth B.

, p. 15 - 20 (1998)

1-Alkylcarbonyloxymethyl (1-ACOM) prodrugs of 5-fluorouracil (5-FU) have been synthesized and characterized by their solubilities in isopropyl myristate (S(IPM)) and pH 4.0 buffer (S(H2O)), by their partition coefficients between isopropyl myristate (IPM) and pH 4.0 buffer (K) and by their abilities to deliver total 5-FU species into (C(s)) and through (J(l)) hairless mouse skin from an IPM vehicle. All of the prodrugs were much more lipophilic (S(IPM)) than 5-FU (>60 times), and two memberS of the series (alkyl = C1 and C2, acelyl- and propionyloxymethyl) were also more soluble in water than 5-FU. The two more water-soluble members gave larger J(l) values than the other members of the series, with C2 exhibiting the best biphasic solubility and the largest J(l) value (16 times that of 5-FU). The ability of the 1-ACOM-5-FU prodrugs to deliver total 5-FU species into skin (C(s)) was greater than the delivery of 5-FU by 5-FU, except for the last two members of series (alkyl = C7 and C9, octanoyl- and decanoyl-oxymethyl). However, the ratios of normalized C(s) to J(l) for the series was less than that exhibited by 5-FU, except for C7 and C9. Also, except for C9, significant amounts of intact prodrug as percentages of total 5-FU species were found in the receptor phases during the course of the diffusion cell experiments, ranging from 55% for C1 to 12% for C7.

5-Fluorouracil derivatives. IV. Synthesis of antitumor-active acyloxyalkyl-5-fluorouracils

Ozaki,Watanabe,Hoshiko,Mizuno,Ishikawa,Mori

, p. 733 - 738 (2007/10/02)

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