66543-11-1

Basic information

• Product Name: Butanoic acid, 4-(methylphenylamino)-3-oxo-, ethyl ester
• CAS NO: 66543-11-1
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Mol File: 66543-11-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-(methylphenylamino)-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-(methylphenylamino)-3-oxo-, ethyl ester(66543-11-1)
• EPA Substance Registry System: Butanoic acid, 4-(methylphenylamino)-3-oxo-, ethyl ester(66543-11-1)

Safety Data

• Hazardous Substances Data: 66543-11-1(Hazardous Substances Data)

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 100-61-8 N-methylaniline 
• 13176-46-0 4-bromoethyl acetoacetate 
• 5000-15-7 sodium N-methylanilide 

Downstream Products

• 56999-62-3 ethyl 2-(1-methyl-1H-indol-3-yl)acetate 
• 1596339-79-5 C₁₁H₁₁N₃O₂ 
• 1596339-53-5 C₁₃H₁₅N₃O₃ 
• 1596339-56-8 C₁₃H₁₅NO₃ 
• 1427461-71-9 C₁₁H₁₃N₃O 

Relevant articles and documents

HETEROARYL COMPOUNDS AND THEIR USE

The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.

Direct amination of γ-Halo-β-ketoesters with anilines

The direct amination of α-haloacetoacetates with anilines is described. Compared to existing methods, this simple protocol provides an attractive strategy to prepare diverse γ-anilino-β-ketoesters in one step. Good to excellent yields of the amination products were obtained under robust conditions, providing versatile and useful scaffolds.