66548-21-8 Usage
General Description
Tert-butyl-methoxy-dimethylsilane is a chemical compound with the molecular formula C7H18OSi. It is a clear, colorless liquid with a strong odor, and is commonly used as a reagent in organosilicon chemistry. It is also known as a tert-butyldimethylsilyloxy group, which is often used as a protecting group in organic synthesis to temporarily mask or protect an alcohol functional group in a molecule. tert-butyl-methoxy-dimethylsilane is utilized in the production of pharmaceuticals, agrochemicals, and other specialty chemicals, as well as in research and development laboratories. Its versatile reactivity and compatibility with a variety of organic molecules make it a valuable tool in synthetic organic chemistry. However, it is important to handle this chemical with caution, as it can be flammable and may pose hazards if not used properly.
Check Digit Verification of cas no
The CAS Registry Mumber 66548-21-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,4 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 66548-21:
(7*6)+(6*6)+(5*5)+(4*4)+(3*8)+(2*2)+(1*1)=148
148 % 10 = 8
So 66548-21-8 is a valid CAS Registry Number.
66548-21-8Relevant articles and documents
Hafnium Triflate as a Highly Potent Catalyst for Regio- and Chemoselective Deprotection of Silyl Ethers
Zheng, Xiu-An,Kong, Rui,Huang, Hua-Shan,Wei, Jing-Ying,Chen, Ji-Zong,Gong, Shan-Shan,Sun, Qi
, p. 944 - 953 (2019/02/10)
As a Group IVB transition metal Lewis acid, hafnium triflate [Hf(OTf) 4 ] exhibited exceptionally high potency in desilylations. Since the amounts of Hf(OTf) 4 required for the deprotection of 1°, 2°, 3° alkyl and aryl tert -butyldimethylsilyl (TBS) ethers are significantly different, ranging from 0.05 mol% to 3 mol%, regioselective deprotection of TBS could be easily implemented. Moreover, chemoselective cleavage of different silyl ethers or removal of TBS in the presence of most hydroxyl protecting groups was also accomplished. NMR analyses of silyl products from TBS deprotection indicated that Hf(OTf) 4 -catalyzed desilylation may proceed via different mechanisms, depending on the solvent used.
