66555-76-8

Basic information

• Product Name: 8-benzyl-1,2,3,4-tetrahydroquinoline
• Synonyms: 8-benzyl-1,2,3,4-tetrahydroquinoline
• CAS NO: 66555-76-8
• Molecular Weight: 223.318
• Mol File: 66555-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-benzyl-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-benzyl-1,2,3,4-tetrahydroquinoline(66555-76-8)
• EPA Substance Registry System: 8-benzyl-1,2,3,4-tetrahydroquinoline(66555-76-8)

Safety Data

• Hazardous Substances Data: 66555-76-8(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 611-32-5 8-methylquinoline 
• 28748-19-8 8-benzylquinoline 

Relevant articles and documents

Ru(II)-Catalyzed Chemoselective C(sp3)-H Monoarylation of 8-Methyl Quinolines with Arylboronic Acids

The transition-metal-promoted C-H activation has become an efficient as well as atom-economic methodology for the synthesis of a wide array of organic molecules, but the cost of the metal catalyst and selectivity remain the major challenges. Herein, the first [Cl2Ru(p-cymene)]2-catalyzed direct monoarylation of unactivated C(sp3)-H bonds of 8-methyl quinolines with arylboronic acids to synthesize diarylmethane compounds is presented. The transformation shows a broad substrate scope with high chemoselectivity for the synthesis of 8-benzyl quinolines. In the preliminary mechanistic studies, control experiments, deuterium labeling experiments, and kinetic studies have been performed.