66558-25-6

Upstream product

• 141-97-9 ethyl acetoacetate 
• 106-47-8 4-chloro-aniline 
• 108-20-3 di-isopropyl ether 
• 57031-90-0 ethyl (Z)-3-hydroxy-2-butenoate 

Downstream Products

• 86397-86-6 diethyl 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate 
• 1602-00-2 bis-(4-chloro-phenyl)-diazene 
• 1125566-37-1 ethyl 3-benzoyl-4-hydroxy-1-(o-hydroxyphenyl)-5-oxo-2,5-dihydro-1H-pyrrole-2-spiro-3'-(5-methyl-1-(p-chlorophenyl)-2-oxo-2,3-dihydro-1H-pyrrole-4-carboxylate) 
• 1125566-38-2 ethyl 4-hydroxy-1-(o-hydroxyphenyl)-3-(p-methoxybenzoyl)-5-oxo-2,5-dihydro-1H-pyrrole-2-spiro-3'-(5-methyl-2-oxo-1-(p-chlorophenyl)-2,3-dihydro-1H-pyrrole-4-carboxylate) 
• 114858-39-8 ethyl 6-chloro-2-methylquinoline-3-carboxylate 
• 74979-93-4 1-(4-Chloro-phenyl)-4-oxo-2,6-diphenyl-piperidine-3-carboxylic acid ethyl ester 
• 74979-96-7 ethyl 1-(4-chlorophenyl)-4-(4-chlorophenylamino)-2,6-bis(phenyl)-1,2,5,6-tetrahydropyridine-3-carboxylate 

Relevant academic research and scientific papers

Highly efficient and facile synthesis of β-enaminones catalyzed by diphenylammonium triflate

Abstract: The catalytic performance of diphenylammonium triflates as an organocatalyst in the synthesis of β-enaminones from various substituted β-diketones and amides (or amines) were evaluated. A wide range of β-enaminones were efficiently synthesized in good to excellent yields under mild reaction conditions. Applying diphenylammonium triflate (DPAT) as catalyst makes this protocol cost-effective, low corrosive and easy to handle. Graphic abstract: [Figure not available: see fulltext.].

Solvent-free synthesis of β-enamino ketones and esters catalysed by recyclable iron(III) triflate

A novel application of highly stable Fe(OTf)3 as an efficient catalyst for the synthesis of a variety of β-enamino ketones and esters under solvent-free conditions is described. Notably, this protocol of a "green synthesis", which produced β-enamino ketones and esters by the reaction of a variety of β-dicarbonyl compounds and primary amines, exhibits attractive properties including high yields, short reaction periods, lower loading of catalyst and chemo- and regio-selectivity. In addition, the catalyst was easily recovered from the reaction system and readily reused with minimal loss of activity.

An efficient chemo-And stereoselective synthesis of enaminones and enaminoesters using (Bromodimethyl)sulfonium bromide under solvent-free conditions

(Bromodimethyl)sulfonium bromide has efficiently been employed for chemo- and stereoselective conversions of β-dicarbonyl compounds into β-enaminones and β-enaminoesters by a treatment with amines at room temperature under solvent-free conditions.

A mild method for the synthesis of β-enaminones and β-enamino esters using KH2P04 as catalyst

β-Enaminones and β-enamino esters have been produced by the direct condensation of amines with β-diketones and β-ketoesters using KH2P04 as catalyst under mild, solvent-free conditions.

Enamination of β-dicarbonyl compounds with amines

Enamination of a wide variety of primary amines was successfully described with excellent chemoselectivity in the presence of catalytic amounts of β-cyclodextrin in water under mild conditions. Aliphatic amines also reacted efficiently to produce the corresponding enaminones.

Efficient synthetic method for β-Enamino esters catalyzed by Yb(OTf)3 under solvent-free conditions

A wide range of ?-enamino esters have been synthesized in moderate to excellent yields by reacting 1,3-dicarbonyl compounds with amines in the presence of catalytic amounts of Yb(OTf)3 (2 mol%). The reaction proceeds smoothly at ambient temperature under solvent-free conditions. The catalyst can be recovered and reused. CSIRO 2006.

A general and efficient method for the preparation of β-enamino ketones and esters catalyzed by indium tribromide

A variety of β-enamino ketones and esters have been synthesized in high to exellent yields by reacting β-dicarbonyl compounds with amines in the presence of a catalytic amount of indium tribromide. The reaction proceeds smoothly at room temperature in a short reaction time under solvent-free conditions.

Hypoglycemic imidazoline compounds

This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases where impaired glucose disposal is present, to pharmaceutical compositions comprising them, and to processes for their preparation.

A novel synthesis of fused pyrazole systems as antimicrobial agents

The pyrazolo[3,4-b]pyridine derivatives 3 could be prepared by condensing compounds 1 with the 3-aminopyrazolone derivative 2. The pyrazolo[5,2-b]-1,3-oxazine derivative 11 and polyfunctionally substituted 1,4-dihydropyridines 15, 18 were also synthesized. Some of the obtained compounds were tested for their antimicrobial activity.

BENTONITE K10 CLAY, AN EFFICIENT CATALYST FOR THE FORMATION OF NITROGEN DERIVATIVES

Bentonite K10 clay has been used to catalyze the formation of enamino carbonyl derivatives, 2-methyl-1H-benzimidazoles, Hantzsch 1,4-dihydropyridines, Hantzsch pyridines, 2-substituted 1,3-diphenylimidazolidines, and tetrahydropyranylbenzazoles.