6656-19-5

Upstream product

• 55323-32-5 10,11-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino-[3,2-a]isoquinolin-7-ium chloride 
• 50-00-0 formaldehyd 
• 109-87-5 Dimethoxymethane 
• 186581-53-3 diazomethane 
• 73777-77-2 polyberbine 
• 19716-54-2 10,11-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-8-one 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 94143-83-6 5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 27972-50-5 5-(3,4-dimethoxy-5-nitro-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline; hydrochloride 
• 47447-28-9 2,3-dimethoxy-5-(5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline 
• 116432-77-0 1-benzo[1,3]dioxol-5-yl-2-(3,4-dimethoxy-phenyl)-ethylamine 
• 802899-46-3 3-benzo[1,3]dioxol-5-yl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline 
• 33466-54-5 10,11-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-5-ol 
• 25888-41-9 1-(2-bromo-4,5-dimethoxybenzyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 1100757-88-7 2,3-methylenedioxy-10,11-dimethoxy-7-benzyltetrahydroprotoberberine bromide 
• 528-67-6 Fagarin II 

Relevant academic research and scientific papers

A General, Concise Strategy that Enables Collective Total Syntheses of over 50 Protoberberine and Five Aporhoeadane Alkaloids within Four to Eight Steps

A concise, catalytic, and general strategy that allowed efficient total syntheses of 22 natural 13-methylprotoberberines within four steps for each molecule is reported. This synthesis represents the most efficient and shortest route to date, featuring three catalytic processes: CuI-catalyzed redox-A3 reaction, Pd-catalyzed reductive carbocyclization, and PtO2-catalyzed hydrogenation. Importantly, this new strategy to the tetracyclic framework has also been applied to the collective concise syntheses of >30 natural protoberberines (without 13-methyl group) and five aporhoeadane alkaloids.

HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF

The present invention relates to a novel hexahydrodibenzo[a,g]quinoline compound represented by general formula (I) and its derivatives, enantiomer, diastereoisomer, raceme and mixtures thereof, as well as pharmaceutically acceptable salts thereof. The pr

Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: Synthesis, structure-activity relationships, and cholesterol-lowering efficacy

Twenty-nine derivatives of berberine (1) or pseudoberberine (2) were designed, semisynthesized, and evaluated for their up-regulatory activity on the low-density-lipoprotein receptor (LDLR) expression. SAR analysis revealed that (i) the methylenedioxy group at the 2- and 3-position is an essential element to keep the activity, (ii) the 7-position quaternary ammonium and planar structure of the compound are activity-required, and (iii) addition of electron-donating groups at the 7- or 13-position reduced the activity. Of the compound 1 analogues, compound 2 exhibited an increased activity on LDLR expression compared to 1.Inthe hyperlipidemic rats, compound 2 (100 (mg/kg)/day) reduced blood CHO and LDL-c by 42.6% and 49.4%, respectively, more efficient than 1 did (p 50 of 2 in mice was over 5000 mg/kg (oral). We consider compound 2 a promising cholesterol- lowering drug candidate.

Aryl radical cyclizations: One-pot syntheses of protoberberine and pavine alkaloids

(equation presented) Treatment of 2-(2′-bromo-β-phenethyl)isocarbostyrils 7 with AIBN Bu3SnH in boiling benzene gave 8-oxoberbines 3 in good yields. A similar treatment of 2-(2′-bromo-β-phenethyl)isoquinolinium bromides 6 and their nor- and hom

Chemical Transformation of Protoberbines. XI. A Novel Synthesis of 2,3,10,11-Tetraoxygenated Protoberberine Alkaloids from Corresponding 2,3,9,10-Tetraoxygenated Protoberberine Alkaloids.

2,3,9,10-Tetraoxygenated protoberberin alkaloids, berberine (1a), palmatine (1b), and coptisine (1c) were efficiently converted into the corresponding 12-hydroxy-2,3,10,11-tetraoxygenated protoberberines (6a, 6b, 6c) through an oxidative C8-C8a bond cleav

TRANSFORMATION OF 2,3,9,10-TETRAOXYGENATED PROTOBERBERINE ALKALOIDS INTO 2,3,10,11-TETRAOXYGENATED PROTOBERBERINE ALKALOIDS

2,3,10,11-Tetraoxygenated tetrahydroprotoberberine (6) were synthesized from the corresponding 2,3,9,10-tetraoxygenated protoberberine alkaloids (1) through oxidative C8-C8a bond cleavage, photocyclization, and deoxygenation.