66567-35-9

Basic information

• Product Name: C₄₆H₆₁O₁₈N₅
• Synonyms: C₄₆H₆₁O₁₈N₅
• CAS NO: 66567-35-9
• Molecular Weight: 972.013
• Mol File: 66567-35-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₆H₆₁O₁₈N₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₆H₆₁O₁₈N₅(66567-35-9)
• EPA Substance Registry System: C₄₆H₆₁O₁₈N₅(66567-35-9)

Safety Data

• Hazardous Substances Data: 66567-35-9(Hazardous Substances Data)

Upstream product

• 42491-79-2 (2S)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropanoic acid 
• 66567-23-5 3,6'-bis-N-benzyloxycarbonylgentamicin B 
• 501-53-1 benzyl chloroformate 
• 61588-19-0 S-(1,3-benzothiazol-2-yl) O-benzyl thiocarbonate 

Downstream Products

• 58152-03-7 isepamicin 

Relevant articles and documents

New convenient reagents for chemoselective N-alkoxycarbonylation of (S)-isoserine: Application in the isepamicin synthesis

A synthesis of a series of N-alkoxycarbonyl mercaptobenzothiazoles (MBTs) and their application as reagents for chemoselective protection of amino group are presented herein. It was shown that all new reagents, Z-MBT, Fmoc-MBT, Phoc-MBT, and Tec-MBT, are highly effective in the selective N-alkoxycarbonylation of (S)-isoserine. The transformation is a simple, fast, and low-cost protocol, which is applicable in scale-up experiments. The starting MBT was fully recovered at the end of the process, which is an additional advantage of the method. The efficiency of the Z-reagent was also demonstrated by the selective protection of both gentamicin B and (S)-isoserine before their peptide-type coupling in the synthesis of the aminoglycoside antibiotic isepamicin. Copyright Taylor & Francis Group, LLC.