66605-66-1

Basic information

• Product Name: (12'R)-hydroxyoctadec-(9'Z)-en-1-yl-4-methylbenzenesulfonate
• Synonyms: (12'R)-hydroxyoctadec-(9'Z)-en-1-yl-4-methylbenzenesulfonate
• CAS NO: 66605-66-1
• Molecular Weight: 438.672
• Mol File: 66605-66-1.mol

Chemical Properties

• CAS DataBase Reference: (12'R)-hydroxyoctadec-(9'Z)-en-1-yl-4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (12'R)-hydroxyoctadec-(9'Z)-en-1-yl-4-methylbenzenesulfonate(66605-66-1)
• EPA Substance Registry System: (12'R)-hydroxyoctadec-(9'Z)-en-1-yl-4-methylbenzenesulfonate(66605-66-1)

Safety Data

• Hazardous Substances Data: 66605-66-1(Hazardous Substances Data)

Upstream product

• 540-11-4 (9Z,12R)-octadec-9-ene-1,12-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 141-24-2 methyl ricinoleate 

Downstream Products

• 182320-75-8 Toluene-4-sulfonic acid (R)-3-hydroxy-nonyl ester 
• 121541-65-9 (R)-(-)-1,3-nonandiol 1 
• 925-78-0 3-nonanone 

Relevant articles and documents

Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists

The transient receptor potential vanilloid type-2 (TRPV2) protein is a nonselective Ca2+ permeable channel member of the TRPV subfamily, still considered an orphan TRP channel due to the scarcity of available selective and potent pharmacological tools and endogenous modulators. Here we describe the discovery of novel synthetic long-chain capsaicin derivatives as potent TRPV2 antagonists in comparison to the totally inactive capsaicin, the role of their hydrophobic chain, and how the structure-activity relationships of such derivatives led, through a ligand-based approach, to the identification of endogenous long-chain fatty acid ethanolamides or primary amides acting as TRPV2 antagonists. Both synthetic and endogenous antagonists exhibited differential inhibition against known TRPV2 agonists characterized by distinct kinetic profiles. These findings represent the first example of both synthetic and naturally occurring TRPV2 modulators with efficacy in the submicromolar/low-micromolar range, which will be useful for clarifying the physiopathological roles of this receptor, its regulation, and its targeting in pathological conditions.

Ozonolysis of ricinolic acid derivatives and transformations of the ozonolysis products under barton reaction conditions

The possibility of functionalizing the alkyl part of ricinolic acid using the Barton reaction was investigated.