66616-71-5

Upstream product

• 1269802-83-6 methyl 3-(4-nitrobiphenyl-3-yl)-2-oxopropanoate 
• 69314-47-2 3-methyl-4-nitrobiphenyl 
• 1381870-29-6 C₁₇H₁₈N₂O₂ 
• 63543-02-2 [1,1'-biphenyl]-4-ylhydrazine hydrochloride 
• 66616-69-1 5-phenyl-1H-indole-2-carboxylic acid ethyl ester 
• 66616-70-4 methyl 5-phenyl-1H-indole-2-carboxylate 
• 7254-19-5 5-bromo-2-indolecarboxylic acid 
• 98-80-6 phenylboronic acid 

Downstream Products

• 66616-72-6 5-phenyl-1H-indole 

Relevant academic research and scientific papers

Structural requirements of acylated Gly- l -Ala- d -Glu analogs for activation of the innate immune receptor NOD2

The fragment of bacterial peptidoglycan muramyl dipeptide (MDP) has long been known for its adjuvant activity, however the underlying mechanism of this action has only recently been elucidated. It is ascribed to its agonist action on the nucleotide-bindin

Some new derivatives of 5-aryl-,2,5-diaryland 2-ethoxycarbonyl-5-aryl- indoles

Some derivatives of 5-aryl-, 2.5-diaryl-, and 2-ethoxycarbonyl-5-aryl- indoles are synthesized. Some reactions of ethyl 5-phenylindole-2-carboxylate are described. It is revealed that an α-ethoxycarbonyl group has a steric and electron-acceptor influence on indole substitution reactions. The structures of all novel compounds are confirmed by IR, UV, 1H NMR, 13C NMR and elemental analyses. ARKAT-USA, Inc.

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells

Highly invasive tumor cells are characterized by a metabolic switch, known as the Warburg effect, from "normal" oxidative phosphorylation to increased glycolysis even under sufficiently oxygenated conditions. This dependence on glycolysis also confers a growth advantage to cells present in hypoxic regions of the tumor. One of the key enzymes involved in glycolysis, the muscle isoform of lactate dehydrogenase (LDH-A), is overexpressed by metastatic cancer cells and is linked to the vitality of tumors in hypoxia. This enzyme may be considered as a potential target for new anticancer agents, since its inhibition cuts cancer energetic and anabolic supply, thus reducing the metastatic and invasive potential of cancer cells. We have discovered new and efficient N-hydroxyindole-based inhibitors of LDH-A, which are isoform-selective (over LDH-B) and competitive with both the substrate (pyruvate) and the cofactor (NADH). The antiproliferative activity of these compounds was confirmed on a series of cancer cell lines, and they proved to be particularly effective under hypoxic conditions. Moreover, NMR experiments showed that these compounds are able to reduce the glucose-to-lactate conversion inside the cell.

Novel 3,4-Dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a

The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.