666215-58-3

Upstream product

• 666215-53-8 4-{2-(tert-butyl-dimethyl-silanyloxy)-1-[6-dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 666215-55-0 (S)-4-{1-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-vinylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 666215-51-6 2-{2-[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-ethyl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester 
• 666215-50-5 2-[2-(1,2-dihydroxy-ethyl)-6-dimethoxymethyl-pyridin-3-yl]-thiazole-4-carboxylic acid ethyl ester 
• 666215-49-2 2-(6-dimethoxymethyl-2-vinyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester 
• 214040-92-3 2-(6-Dimethoxymethyl-2-trifluoromethanesulfonyloxy-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester 
• 666215-56-1 (S)-4-{2-Bromo-1-[6-dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-1-methoxy-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 666215-54-9 (S)-4-{1-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2-hydroxy-ethylcarbamoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 666215-52-7 2-{2-[1-azido-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester 

Downstream Products

• 666215-59-4 (S)-4-[6-Dimethoxymethyl-3-(4-ethoxycarbonyl-thiazol-2-yl)-pyridin-2-yl]-2',2'-dimethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid benzyl ester 
• 666215-61-8 2-(2-{2-[1-benzyloxycarbonylamino-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-oxazol-4-yl}-6-dimethoxymethyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester 
• 666215-62-9 2-(2-{2-[1-amino-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-oxazol-4-yl}-6-dimethoxymethyl-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester 
• 666215-60-7 2-{2-[2-((S)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-oxazol-4-yl]-6-dimethoxymethyl-pyridin-3-yl}-thiazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Useful synthesis of the main central 2,3,6-trisubstituted pyridine skeleton of various thiostrepton-type macrocyclic antibiotics

A useful synthetic method for the main central 2-(2-oxazol-4-yl)-3-(4-thiazol-2-yl)-6-carboxypyridine skeleton [Fragment A] constructing various thiostrepton-type macrocyclic antibiotics is described, in which the precursor of Fragment A was derived from the authentic ethyl 2-(6-dimethoxymethyl-2-trifluoromethanesulfonyloxy-3-pyridyl) thiazole-4-carboxylate in 14 steps. Finally, the fragment condensation of Fragment A with the already prepared carboxy component dipeptide [Fragment B] proceeded first to give the precursor of Fragment A-B.