66628-90-8

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 536-74-3 phenylacetylene 
• 814-16-4 diethyl (3,3-dimethyl-2-oxobutyl)phosphonate 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 66628-94-2 (E)-1-phenyl-3,4,4-trimethyl-1-pentene 
• 66628-93-1 (E)-2,2-Dimethyl-4-phenylhept-5-en-3-on 
• 64976-77-8 (Z)-2,2,4-Trimethyl-6-phenylhex-5-en-3-on 
• 64976-70-1 (E)-2,4,4-Trimethyl-6-phenylhex-5-en-3-on 

Relevant academic research and scientific papers

Controlling the α/γ-Reactivity of Vinylogous Ketone Enolates in Organocatalytic Enantioselective Michael Reactions

The first regio-, diastereo-, and enantioselective direct Michael reaction of β,γ-unsaturated ketones with nitroolefins is enabled by Br?nsted base/hydrogen-bonding bifunctional catalysis. A squaramide-substituted tertiary amine catalyzes the reaction of a broad range of β,γ-unsaturated ketones to proceed at the α-site exclusively, giving rise to adducts with two consecutive tertiary carbon stereocenters in diastereomeric ratios of up to >20:1 and enantioselectivities generally in the 90–98 % ee range.

Transition-metal-free superbase-promoted stereoselective α-vinylation of ketones with arylacetylenes: A general strategy for synthesis of β,γ-unsaturated ketones

A wide variety of β,γ-unsaturated ketones of E configuration have been obtained in good to excellent yields via KOtBu/DMSO promoted α-vinylation of aliphatic, cycloaliphatic, and alkyl aromatic (heteroaromatic) ketones with diverse arylacetylenes.