66638-72-0

Basic information

• Product Name: Z-TRP-MET-OH
• Synonyms: Z-TRP-MET-OH
• CAS NO: 66638-72-0
• Molecular Formula: C₂₄H₂₇N₃O₅S
• Molecular Weight: 469.55
• Mol File: 66638-72-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-TRP-MET-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-TRP-MET-OH(66638-72-0)
• EPA Substance Registry System: Z-TRP-MET-OH(66638-72-0)

Safety Data

• Hazardous Substances Data: 66638-72-0(Hazardous Substances Data)

Usage

General Description

Tryptophan, also known as Z-TRP, is an amino acid found in proteins and essential for the synthesis of serotonin and melatonin. Methionine, abbreviated as MET, is another essential amino acid that plays a vital role in protein synthesis and various cellular processes. Z-TRP-MET-OH is a chemical compound that combines these two amino acids into a single molecule. Z-TRP-MET-OH could potentially have applications in the fields of biochemistry, pharmaceuticals, and nutrition due to the individual health benefits associated with both tryptophan and methionine.

Upstream product

• 106015-56-9 (S)-tert-butyl 2-(1H-imidazole-1-carboxamido)-4-(methylthio)butanoate 
• 1610768-79-0 Cbz-Trp-Met-OtBu 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 4976-72-1 tert-butyl (2S)-2-amino-4-methylsulfanylbutanoate 

Downstream Products

• 1610768-80-3 Cbz-Trp-Met-Val-OtBu 
• 1610768-75-6 C₄₂H₅₃N₅O₇S 
• 1610768-81-4 Cbz-Trp-Met-Val-OH 

Relevant articles and documents

Inverse peptide synthesis via activated α-aminoesters

A mild, practical, and simple procedure for peptide-bond formation is reported. Instead of activation of the carboxylic acid functionality, the reaction involves an unprecedented use of activated α-aminoesters. The method provides a straightforward entry to dipeptides and was effective when a sensitive cysteine residue was used, as no epimerization was detected in this case. The applicability of this method to iterative peptide synthesis was illustrated by the synthesis of a model tetrapeptide in the challenging reverse N→C direction. How to advance by going into reverse: In a mild and practical procedure for peptide-bond formation, free α-aminoesters were activated by treatment with N,N′-carbonyldiimidazole, instead of activating the carboxylic acid functionality (see scheme). The method provided a straightforward route to dipeptides, and its applicability to iterative peptide synthesis was illustrated by the synthesis of a tetrapeptide in the challenging reverse N→C direction.