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N-[4-(3-nitro-phenyl)-thiazol-2-yl]-2-piperidin-1-yl-acetamide is a complex organic compound with the molecular formula C17H18N4O3S. It features a thiazol-2-yl group connected to a nitro-phenyl ring, which is further linked to a piperidin-1-yl-acetamide moiety. N-[4-(3-nitro-phenyl)-thiazol-2-yl]-2-piperidin-1-yl-acetamide is characterized by its potential pharmaceutical applications, often found in the development of drugs targeting various therapeutic areas. Its structure includes a nitro group, which can be significant for its reactivity and potential reduction to an amine group under certain conditions. The compound's specific properties, such as solubility, stability, and pharmacokinetics, are crucial for its application in drug discovery and development.

6664-85-3

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6664-85-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6664-85-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,6 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6664-85:
(6*6)+(5*6)+(4*6)+(3*4)+(2*8)+(1*5)=123
123 % 10 = 3
So 6664-85-3 is a valid CAS Registry Number.

6664-85-3Downstream Products

6664-85-3Relevant academic research and scientific papers

Studies on Cerebral Protective Agents. VIII. Synthesis of 2-Aminothiazoles and 2-Thiazolecarboxamides with Anti-anoxic Activity

Okhubo, Mitsuru,Kuno, Atsushi,Nakanishi,Isao,Takasugi, Hisashi

, p. 1497 - 1504 (2007/10/03)

Various 2-aminothiazoles (2a-s and 3a-g) and 2-thiazolecarboxamides (4a-h), possessing a nitrogeneous basic moiety at the C-2 position of the thiazole ring, were prepared and tested for anti-anoxic (AA) activity in mice.Among them, N-4-(3-trifluoromethylphenyl)-2-thiazolecarbaxamide hydrochloride (4e, FR108143) (minimum effective doses of 3,2 mg/kg i.p. and 10 mg/kg p.o., respectively) exhibited more potent AA activity than either FK360 or compound 1, each of which has a nitrogeneous basic moiety at the C-5 position.The structure-activity relationship with regard to AA activity of this series of compounds are discussed, and the three-dimensional electrostatic potentials (3D-MEP) around the basic nitrogen atom of FK360 and the thiazole derivative (4e) are compared.Key words cerebral protective agent; anti-anoxia; 2-aminothiazole; 2-thiazolecarboxamide; structure-activity relationship; FK360

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