66644-68-6

Usage

Uses

Used in Food and Beverage Industry:
ETHYL 3-METHYLBENZOYLFORMATE is used as a flavoring agent for its fruity odor, enhancing the taste and aroma of various food and drink products.
Used in Cosmetic and Personal Care Products:
ETHYL 3-METHYLBENZOYLFORMATE is used as a fragrance component in cosmetic and personal care products, providing a pleasant scent and improving the sensory experience for users.
Used in Organic Synthesis:
ETHYL 3-METHYLBENZOYLFORMATE is used as a key intermediate in the synthesis of other organic compounds, contributing to the development of new chemical products and materials.
It is important to handle and store ETHYL 3-METHYLBENZOYLFORMATE carefully to avoid exposure and potential hazards, ensuring the safety and quality of the final products in which it is used.

InChI:InChI=1/C11H12O3/c1-3-14-11(13)10(12)9-6-4-5-8(2)7-9/h4-7H,3H2,1-2H3

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 28987-79-3 m-tolylmagnesium bromide 
• 64-17-5 ethanol 
• 1194627-80-9 2-nitro-1-(m-tolyl)ethan-1-one 
• 621-36-3 m-methylphenylacetic acid 
• 40061-55-0 ethyl m-methylphenylacetate 
• 625-95-6 3-Iodotoluene 
• 4755-77-5 Ethyl oxalyl chloride 
• 33675-43-3 1-(bromo-ethynyl)-3-methyl-benzene 
• 2947-60-6 3-methylbenzyl cyanide 
• 142682-68-6 ethyl m-methylphenylimidoacetate hydrochloride 
• 53882-81-8 (3-methylbenzoyl)acetonitrile 
• 108-41-8 1-chloro-3-methylbenzene 
• 591-17-3 meta-bromotoluene 

Downstream Products

• 62281-73-6 ethyl α-hydroxy-3-methylphenylacetate 
• 61560-94-9 3-methylphenyloxoacetic acid 
• 1217169-12-4 ethyl 2-(4-methoxyphenylimino)-2-m-tolylacetate 
• 1254939-25-7 ethyl 2-hydroxy-2-m-tolylpent-4-enoate 
• 1263290-49-8 (R)-ethyl 2-hydroxy-3-nitro-2-(3-tolyl)-propanoate 
• 1282521-51-0 ethyl (S)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(3-methylphenyl)acetate 
• 1282521-62-3 ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(3-methylphenyl)acetate 
• 1613740-02-5 N-methyl-2-oxo-N-phenyl-2-(m-tolyl)acetamide 
• 1613740-05-8 (S)-(methyl(phenyl)amino)-2-oxo-1-(m-tolyl)ethyl 3-phenylpropanoate 
• 1613740-12-7 (S)-(methyl(phenyl)amino)-2-oxo-1-(m-tolyl)ethyl hexanoate 

Relevant academic research and scientific papers

Electrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of α-diazoesters

Electrochemical oxygen reduction reaction (ORR) is a powerful tool for introducing oxygen functional groups in synthetic chemistry. However, compared with the well-developed one-electron oxygen reduction process, the applications of two-electron oxygen re

General Synthesis of Chiral α,α-Diaryl Carboxamides by Enantioselective Palladium-Catalyzed Cross-Coupling

A general synthesis of chiral α,α-diaryl carboxamides is developed by enantioselective cross-coupling between 2-bromo-2-aryl carboxamides and arylboronic acids, leading to a series of chiral α,α-diaryl carboxamides with various electronic properties and functionalities in moderate to excellent enantioselectivities and yields. The employment of a sterically bulky chiral P,P═O ligand L2 is critical for the reactivity and selectivity. This protocol is applied to an efficient asymmetric synthesis of a key intermediate of dopamine receptor agonist SKF 38393.

Controllable chemoselectivity in the coupling of bromoalkynes with alcohols under visible-light irradiation without additives: Synthesis of propargyl alcohols and α-ketoesters

The chemoselectivity of visible-light-induced coupling reactions of bromoalkynes with alcohols can be controlled by simple changes to the reaction atmosphere (N2 or O2). A N2 atmosphere favours propargyl alcohols via a direct C-C coupling process, whereas an O2 atmosphere results in the generation of α-ketoesters through the oxidative CC/C-O coupling pathway.

Ambient and aerobic carbon-carbon bond cleavage toward α-ketoester synthesis by transition-metal-free photocatalysis

The α-oxoesterification of the CC double bond in readily available enaminones enabling efficient synthesis of α-ketoesters is developed. The reactions showing general tolerance to the reactions of primary and secondary alcohols proceed well under air via Rose Bengal (RB)-based photocatalysis. Particularly, this mild synthetic method has been discovered to tolerate various polyhydroxylated substrates such as phenolic alcohol, diols and triols with an excellent selectivity of mono-oxoesterification. What is more noteworthy is that α-ketoester functionalized 16-dehydropregnenolone acetate resulting from the elaboration on a natural product has been obtained practically.

COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY

Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.

Chiral Frustrated Lewis Pairs Catalyzed Highly Enantioselective Hydrosilylations of 1,2-Dicarbonyl Compounds

A highly enantioselective hydrosilylation of 1,2-dicarbonyl compounds was successfully realized for the first time utilizing the combination of tricyclohexylphosphine and chiral alkenylborane derived in situ from diyne as a frustrated Lewis pair catalyst. A variety of optically active α-hydroxy ketones and esters were obtained in 52-98% yields with 86-99% ee's.

Novel Synthesis of α-Keto Esters and Amides by an sp3 C-H Oxidation of Nitromethyl Aryl Ketones Promoted by Ion-Supported (Diacetoxyiodo)benzene

A simple and efficient method is described for the preparation of α-keto esters or amides from nitromethyl aryl ketones. In the presence of nucleophiles (alcohols or amines), the ion-supported (di-acetoxyiodo)benzene-promoted sp3 C-H oxidation of nitromethyl aryl ketones proceeded efficiently under mild conditions to give the corresponding α-keto esters and amides in moderate to good yields. This is the first reported use of (diacetoxyiodo)benzene in the synthesis of α-keto esters and amides. The reaction is ecofriendly and has the -advantages of mild conditions, short reaction times, and a recyclable reagent.

Copper(II)-Catalyzed Benzylic C(sp3)-H Aerobic Oxidation of (Hetero)Aryl Acetimidates: Synthesis of Aryl-α-ketoesters

A straightforward method is developed in this paper for the synthesis of α-ketoesters through copper-catalyzed aerobic oxidation of (hetero)aryl acetimidates using molecular oxygen as a sustainable oxidant. The reaction represents the first example of the direct synthesis of aryl-α-ketoesters from arylacetimidates through the aerobic oxidation of a benzylic C(sp3)-H (CO) bond in moderate to good yield. This transformation occurs under mild reaction conditions with a wide range of substrates and utilizes a readily available oxidant and catalyst. The synthetic utility of this transformation is demonstrated through scaled-up synthesis. A plausible reaction mechanism is also proposed.

A novel method for synthesis of α-keto esters with phenyliodine(III) diacetate

A rapid and efficient synthesis of α-keto esters from β-ketonitriles using phenyliodine(III) diacetate is reported. This protocol gave α-keto esters in good yields. This is the first time to report the application of hypervalent iodine(III) reagents in the synthesis of α-keto esters. A plausible reaction mechanism is proposed.

Cationic Ir/Me-BIPAM-catalyzed asymmetric intramolecular direct hydroarylation of α-ketoamides

Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various types of optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities (84-98 % ee). This is realized by the use of the cationic iridium complex [Ir(cod) 2](BArF4) and the chiral O-linked bidentate phosphoramidite (R,R)-Me-BIPAM. Carbon's got a brand new bond: Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities. This is realized by the use of an asymmetric cationic iridium complex formed in situ (see Scheme).