66644-81-3 Usage
Uses
Used in Menopause Management:
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide is used as a non-hormonal treatment for climacteric flushing. It effectively reduces the frequency and severity of hot flashes associated with menopausal hypoestrogenism, providing an alternative to hormone replacement therapy for women experiencing these symptoms.
Originator
Agreal,Delagrange,France,1980
Manufacturing Process
7.8 g (0.03 mol) of 2,3-dimethoxy-5-sulfamoylbenzoic acid, 200 ml of
tetrahydrofuran and 7.3 g (0.045 mol) of carbonyldimidazole are placed in a
500 ml flask fitted with an agitator, a thermometer and a condenser.The mixture is agitated for 30 minutes at normal temperature, then 6.7 g
(0.948 mol) of 1-allyl-2-aminomethylpyrrolidine is added. The mixture is left
under agitation for 5 hours at 20°C, then the solvent is evaporated under
vacuum and the residue treated with 150 ml of water. The crystals are washed
and dried.
6.9 g of N-(1'-allyl-2'-pyrrolidyl-methyl)-2,3-dimethoxy-5-sulfamoyl-
benzamide is obtained. Yield is 60%; melting point 113°C to 114°C.
Therapeutic Function
Menopause treatment
Check Digit Verification of cas no
The CAS Registry Mumber 66644-81-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,6,4 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 66644-81:
(7*6)+(6*6)+(5*6)+(4*4)+(3*4)+(2*8)+(1*1)=153
153 % 10 = 3
So 66644-81-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H25N3O5S/c1-4-7-20-8-5-6-12(20)11-19-17(21)14-9-13(26(18,22)23)10-15(24-2)16(14)25-3/h4,9-10,12H,1,5-8,11H2,2-3H3,(H,19,21)(H2,18,22,23)
66644-81-3Relevant academic research and scientific papers
N-(1-allyl-2-pyrrolidylmethyl)-2,3-dimethoxy-5-sulfamoylbenzamide and derivatives thereof and method for treating hot flushes associated with natural or surgical menopause
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, (2008/06/13)
N-(1'-allyl-2'-pyrrolidylmethyl)-2,3-dimethoxy-5-sulfamoylbenzamide and dvatives thereof and method for treating the psycho neuro-vegetative syndrome of the natural or surgical menopause by administering an effective amount of said compound to a patient.
