6665-69-6

Basic information

• Product Name: 3,5-DIHYDROXYFLAVONE
• Synonyms: 3,5-DIHYDROXYFLAVONE
• CAS NO: 6665-69-6
• Molecular Formula: C₁₅H₁₀O₄
• Molecular Weight: 254.24
• Product Categories: Di-substituted Flavones
• Mol File: 6665-69-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 145-146 °C
• Boiling Point: 451.8°C at 760 mmHg
• Flash Point: 175.4°C
• Appearance: /
• Density: 1.472g/cm³
• Vapor Pressure: 5.97E-09mmHg at 25°C
• Refractive Index: 1.712
• PKA: 6.58±0.40(Predicted)
• CAS DataBase Reference: 3,5-DIHYDROXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIHYDROXYFLAVONE(6665-69-6)
• EPA Substance Registry System: 3,5-DIHYDROXYFLAVONE(6665-69-6)

Safety Data

• Hazardous Substances Data: 6665-69-6(Hazardous Substances Data)

Usage

Uses

3,5-Dihydroxyflavone (CAS# 6665-69-6) is a flavenoid which, as a class of compounds, have broad pharmacological activity, including binding to biomolecules such as enzymes, hormone carriers, and DNA, chelating transition metal ions, catalyzing electron transport, and scavenging free radicals.

InChI:InChI=1/C15H10O4/c16-10-7-4-8-11-12(10)13(17)14(18)15(19-11)9-5-2-1-3-6-9/h1-8,16,18H

Upstream product

• 577-85-5 3-hydroxyflavone 
• 106-33-2 ethyl laurate 
• 78433-52-0 3,5-dimethoxy-2-phenyl-chromen-4-one 
• 40524-67-2 (E)-1-(2-hydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one 
• 55947-36-9 5-methoxyflavanone 
• 6665-81-2 3-Hydroxy-5-methoxyflavone 

Downstream Products

• 727381-93-3 5-hydroxy-3-methoxy-2-phenyl-chromen-4-one 
• 1242087-57-5 3,5-Dihydroxyflavone 3-glucuronide 
• 853931-05-2 5-hydroxy-3,8-dimethoxy-4-oxo-2-phenyl-4H-chromene-6-carbaldehyde 
• 727413-36-7 3,5,8-trimethoxy-2-phenyl-chromen-4-one 
• 743431-07-4 5-hydroxy-3,8-dimethoxy-2-phenyl-chromen-4-one 
• 859050-47-8 5,8-dihydroxy-3-methoxy-2-phenyl-chromen-4-one 
• 727412-95-5 3,5,8-trihydroxy-2-phenyl-chromen-4-one 

Relevant articles and documents

Ru(II)-Catalyzed Site-Selective Hydroxylation of Flavone and Chromone Derivatives: The Importance of the 5-Hydroxyl Motif for the Inhibition of Aurora Kinases

An efficient protocol for Ru(II)-catalyzed direct C-H oxygenation of a broad range of flavone and chromone substrates was developed. This convenient and powerful synthetic tool allows for the rapid installation of the hydroxyl group into the flavone, chromone, and other related scaffolds and opens the way for analog synthesis of highly potent Aurora kinase inhibitors. The molecular docking simulations indicate that the formation of bidentate H-bonding patterns in the hinge regions between the 5-hydroxyflavonoids and Ala213 was the significant binding force, which is consistent with experimental and computational findings.