6665-69-6

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Dihydroxyflavone is used as a pharmaceutical agent for its diverse biological activities. Its ability to bind to various biomolecules and chelate metal ions makes it a promising candidate for the development of drugs targeting a range of health conditions.
Used in Nutraceutical Industry:
In the nutraceutical industry, 3,5-dihydroxyflavone is utilized as a dietary supplement due to its antioxidant properties. Its capacity to scavenge free radicals contributes to its potential health benefits, supporting overall wellness and possibly reducing the risk of certain diseases.
Used in Cosmetic Industry:
3,5-Dihydroxyflavone is employed in cosmetic products for its potential skin health benefits. Its antioxidant and metal ion chelating properties may contribute to skin protection and rejuvenation, making it a valuable ingredient in skincare formulations.
Used in Agricultural Industry:
In agriculture, 3,5-dihydroxyflavone may be used as a natural pesticide or growth promoter. Its ability to bind to biomolecules could potentially influence plant-pathogen interactions, offering a more sustainable approach to crop protection and enhancement.

InChI:InChI=1/C15H10O4/c16-10-7-4-8-11-12(10)13(17)14(18)15(19-11)9-5-2-1-3-6-9/h1-8,16,18H

Upstream product

• 6665-81-2 3-Hydroxy-5-methoxyflavone 
• 106-33-2 ethyl laurate 
• 78433-52-0 3,5-dimethoxy-2-phenyl-chromen-4-one 
• 577-85-5 3-hydroxyflavone 
• 40524-67-2 (E)-1-(2-hydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one 
• 55947-36-9 5-methoxyflavanone 

Downstream Products

• 1242087-57-5 3,5-Dihydroxyflavone 3-glucuronide 
• 853931-05-2 5-hydroxy-3,8-dimethoxy-4-oxo-2-phenyl-4H-chromene-6-carbaldehyde 
• 727413-36-7 3,5,8-trimethoxy-2-phenyl-chromen-4-one 
• 743431-07-4 5-hydroxy-3,8-dimethoxy-2-phenyl-chromen-4-one 
• 859050-47-8 5,8-dihydroxy-3-methoxy-2-phenyl-chromen-4-one 
• 727412-95-5 3,5,8-trihydroxy-2-phenyl-chromen-4-one 
• 727381-93-3 5-hydroxy-3-methoxy-2-phenyl-chromen-4-one 

Relevant academic research and scientific papers

Ru(II)-Catalyzed Site-Selective Hydroxylation of Flavone and Chromone Derivatives: The Importance of the 5-Hydroxyl Motif for the Inhibition of Aurora Kinases

An efficient protocol for Ru(II)-catalyzed direct C-H oxygenation of a broad range of flavone and chromone substrates was developed. This convenient and powerful synthetic tool allows for the rapid installation of the hydroxyl group into the flavone, chromone, and other related scaffolds and opens the way for analog synthesis of highly potent Aurora kinase inhibitors. The molecular docking simulations indicate that the formation of bidentate H-bonding patterns in the hinge regions between the 5-hydroxyflavonoids and Ala213 was the significant binding force, which is consistent with experimental and computational findings.

Inhibitors of cyclin dependent kinases

The invention provides novel inhibitors of cyclin-dependent kinases, in particular inhibitors of the CDK/cyclin complexes such as CDK4/cyclin D1. The novel compounds are analogs of chromones. These compounds can be used for inhibiting excessive or abnormal cell proliferation. Thus, the novel compounds are useful for treating a subject with a disorder associated with excessive cell proliferation, such as cancer.