66658-57-9

Upstream product

• 6342-60-5 2-chloro-5-methyl-benzoic acid 
• 16220-99-8 5-bromomethyl-2-chloro-benzoic acid methyl ester 

Downstream Products

• 301672-76-4 5-bromomethyl-2-chloro-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)-benzamide 
• 301672-78-6 5-(bromomethyl)-2-chloro-N-(2-tricyclo[3.3.1.13.7]dec-1-ylethyl)-benzamide 
• 301672-79-7 4-[[4-Chloro-3-[[(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)amino]carbonyl]-phenyl]methyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester 
• 301672-56-0 2-Chloro-5-[(5,6-dihydro-1(4H)-pyrimidinyl)methyl]-N-(tricyclo[3.3.1.13.7]dec-1-ylmethyl)-benzamide 
• 301672-94-6 4-[[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 
• 1179337-94-0 2-Chloro-5-(2-hydroxyethyl)benzaldehyde 
• 66658-58-0 2-chloro-5-(cyanomethyl)benzoic acid 
• 1179337-93-9 2-(4-chloro-3-(hydroxymethyl)phenyl)ethanol 
• 1179337-92-8 5-(carboxymethyl)-2-chlorobenzoic acid 
• 1187239-03-7 C₂₈H₂₇BrClNO₅S 

Relevant academic research and scientific papers

BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to benzamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, n and Y are as defined in the description, their preparation and their use as pharmaceutically active compounds.

BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to benzamide derivatives of formula (I),wherein R1, R2, R3, R4, R5, R6, n and Y are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.

Discovery of potent and selective adamantane-based small-molecule P2X 7 receptor antagonists/interleukin-1β inhibitors

A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of t

Adamantane derivatives

The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CHs

Adamantane derivatives

The invention provides compounds of general formula in which m, A, R1and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.