66659-90-3

Upstream product

• 1002717-44-3 1,2-bis(p-trifluoromethylphenyl)ethylene 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 25753-16-6 4-(trifluoromethyl)benzoic anhydride 
• 108-94-1 cyclohexanone 
• 103411-25-2 4-(trifluoromethyl)(trimethylsilyl)methanone 

Downstream Products

• 73790-20-2 4,4'-bis(trifluoromethyl)benzil 
• 455-24-3 4-trifluoromethylbenzoic acid 

Relevant academic research and scientific papers

A structureeactivity relationship study on the Wacker oxidation of stilbenes at ambient condition

To evaluate which structural elements of the stilbenes are responsible for their activity on the Wacker oxidation, a series of stilbenes with various functional moieties and substitution patterns were considered. In this regard, it is found that the oxidation rate of stilbenes strongly depends on their structures to give the corresponding carbonyl compounds. Consequently, the ortho position of alkene and methoxy groups plays a key role in the complexation with PdCl2. The oxidation process is clean with high selectivity of product and low percentage of byproducts.

Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists

A novel series of 4,5-biarylimidazoles as TRPV1 antagonists were designed based on the previously reported 4,6-disubstituted benzimidazole series. The analogs were evaluated for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. These studies led to the identification of a highly potent and orally bioavailable TRPV1 antagonist, imidazole 33.

Vanilloid receptor ligands and their use in treatments

Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Palladium-Catalyzed Cross-Coupling Reactions of Carboxylic Anhydrides with Organozinc Reagents

(Matrix presented) Negishi-type cross-coupling reaction was effected by employing organozincs and anhydrides or mixed anhydrides that formed in situ from sodium salts of the corresponding acids and ethyl chloroformate under the catalysis of palladium(0). A general method for preparing symmetrical/ unsymmetrical ketones was developed.

TiCl4-Zn induced reductive acylation of ketones with acylsilanes

Acylsilanes were found to react with ketones in the presence of a low-valent titanium reagent generated from titanium(IV) chloride and zinc, giving the corresponding reductive acylated compounds.

6-Hydroxy-5,6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles

The compounds are 6-hydroxy-5,6-substituted-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles which have antiarthritic activity and are useful as intermediates for preparing 2,3-dihydroimidazo[2,1-b]thiazole antiarthritic compounds. A particular compound o