66663-90-9 Usage
Description
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalacin D2 has anti-cancer activity, it exhibits significant inhibition on the proliferation of five kinds of cultured human tumor cell lines.
Biological Activity
Platycodin D2 is a saponin isolated from Platycodon grandiflorum, with anti-cancer activity.
in vitro
A novel triterpenoid saponin, deapioplatycoside Ewas isolated from the root extract of Platycodon grandiflorum, together with the seven known saponins 2 - 8, i. e., platycoside E, deapioplatycodin D3 , platycodin D3, polygalacin D2, Platycodin D2 , deapioplatycodin D and platycodin D. The structure of the new saponin 1 was determined on the basis of spectral analysis and chemical evidence.
Check Digit Verification of cas no
The CAS Registry Mumber 66663-90-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,6,6 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 66663-90:
(7*6)+(6*6)+(5*6)+(4*6)+(3*3)+(2*9)+(1*0)=159
159 % 10 = 9
So 66663-90-9 is a valid CAS Registry Number.
66663-90-9Relevant articles and documents
Saponins from Roots of Platycodon grandiflorum. Part 2. Isolation and Structure of New Triterpene Glycosides
Ishii, Hiroshi,Tori, Kazuo,Tozyo, Takehiko,Yoshimura, Yohko
, p. 661 - 668 (2007/10/02)
Seventeen new saponins (2)-(18) have been isolated from the roots of Platycodon grandiflorum A.DC. and their structures determined by comparison of their 13C n.m.r. signals with those of known prosapogenins (19)-(26) and of the sugar chain at C-28 in platycodin-D (1).Eight of these saponins were found to have an O-acetyl group which migrated both readily and reversibly between the 2-O- and 3-O-positions of the rhamnose moiety in their sugar chain.
