666702-76-7

Upstream product

• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 

Downstream Products

• 1778-09-2 4-(Methylthio)acetophenone 
• 53458-17-6 1,2-bis(4-methylsulfanyl-phenyl)ethane-1,2-dione 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 666702-80-3 2-azide-1-(4'-thiomethylphenyl)vinyl propionate 
• 145412-92-6 2-amino-1-(4-methylsulfanyl-phenyl)-ethanol 
• 1184850-61-0 2-azido-1-(4-methylsulfanyl-phenyl)-ethanol 

Relevant academic research and scientific papers

ARYL-HYDROXYETHYLAMINO-PYRIMIDINES AND TRIAZINES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE

Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

Competition between α-cleavage and energy transfer in α-azidoacetophenones

(Chemical Equation Presented) Molecular modeling demonstrates that the first excited state of the triplet ketone (T1K) in azide 1b has a (π,π*) configuration with an energy that is 66 kcal/mol above its ground state and its second excited state (T2K) is 10 kcal/mol higher in energy and has a (n,π*) configuration. In comparison, T 1K and T2K of azide 1a are almost degenerate at 74 and 77 kcal/mol above the ground state with a (n,π*) and (π,π*) configuration, respectively. Laser flash photolysis (308 nm) of azide 1b in methanol yields a transient absorption (λmax = 450 nm) due to formation of T1K, which decays with a rate of 2.1 × 10 -5 s-1 to form triplet alkylnitrene 2b (λmax = 320 nm). The lifetime of nitrene 2b was measured to be 16 ms. In contrast, laser flash photolysis (308 nm) of azide 1a produced transient absorption spectra due to formation of nitrene 2a (λ max = 320 nm) and benzoyl radical 3a (λmax = 370 nm). The decay of 3a is 2 × 10-5 s-1 in methanol, whereas nitrene 2a decays with a rate of ～91 s-1. Thus, T 1K (π,π*) in azide 1b leads to energy transfer to form nitrene 2b; however, α-cleavage is not observed since the energy of T 2K (n,π*) is 10 kcal/mol higher in energy than T 1K, and therefore, T2K is not populated. In azide 1a both α-cleavage and energy transfer are observed from T1K (n,π*) and T2K (π,π*), respectively, since these triplet states are almost degenerate. Photolysis of azide 1a yields mainly product 4, which must arise from recombination of benzoyl radicals 3a with nitrenes 2a. However, products studies for azide 1b also yield 4b as the major product, even though laser flash photolysis of azide 1b does not indicate formation of benzoyl radical 3b. Thus, we hypothesize that benzoyl radicals 3 can also be formed from nitrenes 2. More specifically, nitrene 2 does undergo α-photocleavage to form benzoyl radicals and iminyl radicals. The secondary photolysis of nitrenes 2 is further supported with molecular modeling and product studies.

Azole antifungal agents, processes for the preparation thereof, and intermediates

A compound represented by the general formula: wherein R1 and R2 denote a halogen atom or hydrogen atoms; R3 means a hydrogen atoms or lower alkyl group; r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic rings, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for -S-, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.

Antifungal agents, and compositions

A compound represented by the general formula: STR1 wherein R1 and R2 denote a halogen atom or hydrogen atom; R3 means a hydrogen atom or lower alkyl group; l, r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic ring, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for --S--, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.