666721-60-4

Basic information

• Product Name: Cyclohexanecarboxylic acid, 4-[[[[4-[4-(trifluoromethoxy)phenyl]-2-thienyl]carbonyl]amino]methyl]-, trans-
• CAS NO: 666721-60-4
• Molecular Formula: C20H20F3NO4S
• Molecular Weight: 427.444
• Mol File: 666721-60-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxylic acid, 4-[[[[4-[4-(trifluoromethoxy)phenyl]-2-thienyl]carbonyl]amino]methyl]-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 4-[[[[4-[4-(trifluoromethoxy)phenyl]-2-thienyl]carbonyl]amino]methyl]-, trans-(666721-60-4)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 4-[[[[4-[4-(trifluoromethoxy)phenyl]-2-thienyl]carbonyl]amino]methyl]-, trans-(666721-60-4)

Safety Data

• Hazardous Substances Data: 666721-60-4(Hazardous Substances Data)

Upstream product

• 666721-04-6 4-[4-(trifluoromnethoxy)phenyl]thiophene-2-carbonyl chloride 
• 1197-18-8 trans-4-aminomethyl-cyclohexyl-carboxylic acid 
• 666721-06-8 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic acid 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 16694-18-1 4-bromo-thiophene-2-carboxylic acid 

Relevant articles and documents

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors

A new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Modeling studies using a known MMP-12 crystal structure identified a new interaction mode for these new MMP-12 inhibitors. Further optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 and which was co-crystallized with MMP-12.