666726-33-6Relevant articles and documents
Discovery and SAR study of novel dihydroquinoline containing glucocorticoid receptor ligands
Takahashi, Hidenori,Bekkali, Younes,Capolino, Alison J.,Gilmore, Thomas,Goldrick, Susan E.,Nelson, Richard M.,Terenzio, Donna,Wang, Ji,Zuvela-Jelaska, Ljiljana,Proudfoot, John,Nabozny, Gerald,Thomson, David
, p. 1549 - 1552 (2007/10/03)
We report the discovery of a novel class of glucocorticoid receptor (GR) ligands based on 1,2-dihydroquinoline molecular scaffold. The compounds exhibit good GR binding affinity and selectivity profile against other nuclear hormone receptors.
GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
-
Page 63, (2010/02/06)
Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, X, Y, and n are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.