66684-58-0

Basic information

• Product Name: 3,4,5-Trifluoronitrobenzene
• Synonyms: 1,2,3-TRIFLUORO-5-NITROBENZENE;3,4,5-TRIFLUORONITROBENZENE;1-NITRO-3,4,5-TRIFLUOROBENZENE;3,4,5-TRIFLUORO NITROBENZENE 99% MINIMUM;1,2,3-Trifluoro-5-nitrobenzene, 1-Nitro-3,4,5-trifluorobenzene;3,4,5-Trifluoronitro;5-Trifluoronitrobenzene;5-Nitro-1,2,3-trifluorobenzene
• CAS NO: 66684-58-0
• Molecular Formula: C₆H₂F₃NO₂
• Molecular Weight: 177.08
• EINECS: 266-447-0
• Product Categories: Fluorobenzene Series;Fluorobenzene;API intermediates;Miscellaneous;Benzenes
• Mol File: 66684-58-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 208.6 °C at 760 mmHg
• Flash Point: 167 °F
• Appearance: /
• Density: 1.517 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: n20/D 1.486(lit.)
• Storage Temp.: Room temperature.
• BRN: 2455018
• CAS DataBase Reference: 3,4,5-Trifluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-Trifluoronitrobenzene(66684-58-0)
• EPA Substance Registry System: 3,4,5-Trifluoronitrobenzene(66684-58-0)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 66684-58-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C7H5F2NO3/c1-13-5-3-2-4(10(11)12)6(8)7(5)9/h2-3H,1H3

Upstream product

• 163733-96-8 3,4,5-trifluoro aniline 
• 5580-79-0 2,3,4,5-tetrafluoro-1-nitrobenzene 
• 880-78-4 pentafluoronitrobenzen 
• 148416-38-0 6-nitro-2,3,4-trifluoroaniline 

Downstream Products

• 543683-36-9 2-(2,6-difluoro-4-nitrophenyl)acetic acid 
• 549547-30-0 4-(4-fluorophenoxy)-3,5-difluoronitrobenzene 
• 383199-85-7 4-(2,6-difluoro-4-nitrophenyl)thiomorpholine 
• 590421-61-7 1-(2,6-difluoro-4-nitrophenyl)-2,5-dihydro-1H-pyrrole 
• 504438-19-1 [(1α,5α,6α)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester 
• 681425-49-0 3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane 
• 590421-32-2 ethyl 2-cyano-2-(4-nitro-2,6-difluorophenyl)propionate 
• 919357-37-2 1-(2,6-difluoro-4-nitrophenyl)-3-methylazetidin-3-ol 
• 919356-97-1 1-(2,6-difluoro-4-nitrophenyl)-3,3-difluoroazetidine 
• 337520-54-4 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene 
• 1015414-83-1 5'-methoxy-4-nitro-2,2',6-trifluorobenzophenone 
• 1309652-90-1 C₁₁H₉F₂NO₆ 

Relevant articles and documents

Copper-catalyzed hydrodefluorination of fluoroarenes by copper hydride intermediates

Breaking bad: Efficient copper-catalyzed C-F bond activation has been achieved by replacing fluorine with hydrogen. A copper hydride is proposed as the active intermediate, which proceeds through a nucleophilic attack on the fluorocarbon, as determined by experimental and theoretical results (see structure; C gray, H white, Cu light red, F light blue; distances in ?).

RHO-KINASE INHIBITORS

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PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS

The invention relates to the phenylaminopyrimidines of formula (I), wherein A, D, R1, R2, R3 and R4 are defined as in the description. The invention also relates to methods for producing said phenylaminopyrimidines and to their use for producing drugs for the treatment and/or the prophylaxis of diseases, especially cardiovascular diseases.