666841-73-2Relevant academic research and scientific papers
Design, synthesis, and anticancer activity of novel aryl/heteroaryl chalcone derivatives
Arasavelli, Ananda Mohan,Raghava Sharma, Ganapavarapu Veera,Vidavalur, Siddaiah
, p. 1 - 5 (2016)
A new series of chalcones 5a-l were synthesized and evaluated for in vitro antiproliferative activity against human colon cancer cell lines. The synthesis of the key intermediate compounds 3a-d was achieved by tetrakis(triphenylphosphine) palladium(II) mediated Suzuki cross coupling reaction. Chalcone 5a shows superior anticancer activity with IC50 value of 21.0 μg/mL compared to the IC50 value of the reference drug doxorubicin at 21.65 μg/mL.
Palladium/tetraphosphine catalyzed suzuki cross-coupling of heteroarylboronic acids with aryl halides
Kondolff, Isabelle,Doucet, Henri,Santelli, Maurice
, p. 109 - 118 (2008/09/18)
(Chemical Equation Presented) cis,cis,cis-1,2,3,4- Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C3H 5)]2 efficiently catalyses the Suzuki reaction of heteroarylboronic acids with aryl bromides and also the coupling of arylboronic acids with heteroaryl bromides. The coupling of thiophene- or benzothiopheneboronic acids, furan- or benzofuranboronic acids and 3-pyridineboronic acid with a variety of aryl bromides gave the corresponding coupling products in good yields. However, in most cases, better results in terms of ratio substrate/catalyst were obtained for the reverse reaction using heteroaryl bromides with arylboronic acids.
Towards new neuroprotective agents: Design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors
Pellicciari, Roberto,Camaioni, Emidio,Costantino, Gabriele,Marinozzi, Maura,Macchiarulo, Antonio,Moroni, Flavio,Natalini, Benedetto
, p. 851 - 858 (2007/10/03)
An excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme able to catalyze the transfer of ADP-ribose from NAD to acceptor proteins, is involved in the progression of neuronal damage after brain insult. Potent and selective PARP-
