66685-93-6

Upstream product

• 63316-04-1 methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate 
• 6775-11-7 bis(2-(carbomethoxy)ethyl)phenylphosphine 
• 23855-87-0 1-phenyl-4-phosphorinanone 

Downstream Products

• 83206-21-7 1-(1,2,3,6-tetrahydro-1-phenyl-4-phosphorinyl)pyrrolidine P-sulfide 
• 344305-15-3 3-(1'-oxoethyl)-1-phenyl-4-phosphorinanone 1-sulfide 
• 33696-92-3 4-methylene-1-phenyl-phosphinane 1-sulfide 

Relevant academic research and scientific papers

Desymmetrization Approach to the Synthesis of Optically Active P-Stereogenic Phosphin-2-en-4-ones

Two synthetic protocols for the conversion of 1-phenylphosphinan-4-ones to novel P-stereogenic 1-phenylphosphin-2-en-4-ones by enantioselective deprotonation followed by oxidation and by asymmetric organocatalytic halogenation accompanied by elimination have been developed. These two-step one-pot transformations provide convenient access to optically active 1-phenylphosphin-2-en-4-one 1-sulfide and 1-phenylphosphin-2-en-4-one 1-oxide of 96 and 55% enantiomeric purities, respectively.