666850-79-9

Upstream product

• 666852-79-5 2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-4-(2-chloroethyl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole 
• 63214-57-3 (morpholin-4-yl)(piperidin-4-yl)methanone 
• 50910-54-8 trans-4-aminocyclohexanol hydrochloride 
• 666852-65-9 ethyl 2-{5-[(tert-butoxycarbonyl)amino]-2-thienyl}-2-methylpropanoate 
• 666852-64-8 ethyl 2-methyl-2-(5-nitro-2-thienyl)propanoate 
• 666852-77-3 2-[5-(3,5-dimethylphenyl)-4-(2-hydroxyethyl)-6H-thieno[2,3-b]pyrrol-2-yl]-2-methylpropanoic acid 
• 666852-63-7 ethyl 2-methyl-2-(2-thienyl)propanoate 
• 94467-73-9 morpholino(piperidine-4-yl)methanone hydrochloride 

Downstream Products

• 863561-51-7 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor

A new class of small-molecule GnRH antagonists, the thieno[2,3-b]pyrroles, was designed. Herein, the synthesis and structure-activity relationships are described. Substitution at the C4 position was investigated; during this study, it was observed that in

PYRROLE DERIVATIVES AS GONADOTROPIN RELEASING HORMONE (GNRH) ANTAGONISTS

The invention relates to a group of novel thieno-pyrrole compounds of formula (I) wherein: R1,R2, R3, R4 M, and R5 are as defined in the specification, as inter alia, gonadotrophin releasing hor

6H-THIENO`2, 3-B!PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)

The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.