666861-81-0

Basic information

• Product Name: 3-(benzyloxyamino)propanoic acid tert-butyl ester
• Synonyms: 3-(benzyloxyamino)propanoic acid tert-butyl ester
• CAS NO: 666861-81-0
• Molecular Weight: 251.326
• Mol File: 666861-81-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3-(benzyloxyamino)propanoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(benzyloxyamino)propanoic acid tert-butyl ester(666861-81-0)
• EPA Substance Registry System: 3-(benzyloxyamino)propanoic acid tert-butyl ester(666861-81-0)

Safety Data

• Hazardous Substances Data: 666861-81-0(Hazardous Substances Data)

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 29601-98-7 N-benzylhydroxylamine hydrochloride 
• 622-33-3 N-benzyloxyamine 

Downstream Products

• 1239468-30-4 3-[(benzyloxy)(6-bromohexanoyl)amino]propanoic acid tert-butyl ester 
• 1255910-87-2 3-[(benzyloxy)(9-bromononanoyl)amino]propanoic acid tert-butyl ester 
• 1239468-35-9 3-[(benzyloxy)(11-bromoundecanoyl)amino]propanoic acid tert-butyl ester 
• 1239468-31-5 3-[(benzyloxy)(7-bromoheptanoyl)amino]propanoic acid tert-butyl ester 
• 1239468-38-2 3-[benzyloxy(7-methyloctanoyl)amino]propanoic acid tert-butyl ester 
• 1239468-32-6 3-[(benzyloxy)(8-bromooctanoyl)amino]propanoic acid tert-butyl ester 
• 1239468-36-0 3-[(benzyloxy)(12-bromododecanoyl)amino]propanoic acid tert-butyl ester 
• 1239468-34-8 3-[(benzyloxy)(10-bromodecanoyl)amino]propanoic acid tert-butyl ester 
• 170455-85-3 3-[acetyl(benzyloxy)amino]propanoic acid tert-butyl ester 
• 1454255-87-8 C₂₂H₄₁NO₄ 
• 1454255-89-0 C₂₂H₃₅NO₄ 
• 1454255-78-7 C₂₄H₃₉NO₄ 
• 1454255-79-8 tert-butyl 3-(N-benzyloxy-9-cyclopropylnonanamido)propanoate 
• 1454255-80-1 C₂₈H₄₅NO₄ 

Relevant articles and documents

CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES

A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.

4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A

Overexpression of the histone lysine demethylase KDM4A, which regulates H3K9 and H3K36 methylation states, has been related to the pathology of several human cancers. We found that a previously reported hydroxamate-based histone deacetylase (HDAC) inhibitor (SW55) was also able to weakly inhibit this demethylase with an IC50value of 25.4 μm. Herein we report the synthesis and biochemical evaluations, with two orthogonal in vitro assays, of a series of derivatives of this lead structure. With extensive chemical modifications on the lead structure, also by exploiting the versatility of the radical arylation with aryldiazonium salts, we were able to increase the potency of the derivatives against KDM4A to the low-micromolar range and, more importantly, to obtain demethylase selectivity with respect to HDACs. Cell-permeable derivatives clearly showed a demethylase-inhibition-dependent antiproliferative effect against HL-60 human promyelocytic leukemia cells.

New hydroxamic acid derivative and use thereof

PROBLEM TO BE SOLVED: To provide a novel hydroxamic acid derivative having an inhibitory activity against KDM7 being a histone demethylase, and a cancer cell proliferation-suppressing action, and to provide medicines (particularly a KDM7 inhibitor and anticancer agent) using the derivative.SOLUTION: A compound represented by general formula (I) (wherein R is a linear, branched or annular alkyl group; and n is an integer of ≥6), a salt thereof, hydrate, solvate or prodrug are provided. The compound can be used as a medicine (particularly an anticancer agent) or a KDM7 inhibitor.