66692-72-6

Basic information

• Product Name: (-)-2-[(1E,3E)-1,3-Hexadienyl]-5-methoxy-2-methyl-4-[(E)-1-oxo-2-hexenyl]furan-3(2H)-one
• Synonyms: (-)-2-[(1E,3E)-1,3-Hexadienyl]-5-methoxy-2-methyl-4-[(E)-1-oxo-2-hexenyl]furan-3(2H)-one;Graminin A
• CAS NO: 66692-72-6
• Molecular Formula: C18H24O4
• Molecular Weight: 304.38
• Mol File: 66692-72-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (-)-2-[(1E,3E)-1,3-Hexadienyl]-5-methoxy-2-methyl-4-[(E)-1-oxo-2-hexenyl]furan-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-2-[(1E,3E)-1,3-Hexadienyl]-5-methoxy-2-methyl-4-[(E)-1-oxo-2-hexenyl]furan-3(2H)-one(66692-72-6)
• EPA Substance Registry System: (-)-2-[(1E,3E)-1,3-Hexadienyl]-5-methoxy-2-methyl-4-[(E)-1-oxo-2-hexenyl]furan-3(2H)-one(66692-72-6)

Safety Data

• Hazardous Substances Data: 66692-72-6(Hazardous Substances Data)

Upstream product

• 76783-21-6 3-methyl-1,4-pentadiyne-3-ol 
• 58801-71-1 methyl {(R)-5-[(E,E)-hexa-1,3-dienyl]-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-yl}carboxylate 
• 123-72-8 butyraldehyde 

Relevant articles and documents

Total Synthesis of (-)-Graminin A Based on Asymmetric Cyclization Carbonylation of Propargyl Acetate

The first total synthesis of (-)-graminin A is described. Key features of our synthetic approach involve a palladium-catalyzed asymmetric cyclization carbonylation of prochiral propargylic acetate, conversion of the orthoester product into methyl 4-oxo-3-furancarboxylate, and copper complex-mediated aldol condensation of (+)-gregatin B bearing a diene moiety. A new synthesis of (+)-gregatin B and the first synthesis of (-)-graminin A were achieved.