66696-91-1

Upstream product

• 1206636-16-9 (±)-benzyl hepta-2,3-dienoate 
• 638-29-9 n-valeryl chloride 
• 7737-62-4 Ethyl 3-oxoheptanoate 
• 100-51-6 benzyl alcohol 
• 66696-78-4 5-(1-hydroxypentylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 188526-20-7 2-diazo-3-oxo-heptanoic acid benzyl ester 
• 188526-22-9 5-butyl-2-oxo-[1,3]dioxole-4-carboxylic acid benzyl ester 
• 188526-21-8 2-hydroxy-3-oxo-heptanoic acid benzyl ester 

Relevant academic research and scientific papers

Oxone-promoted hydration of electron-deficient allenic esters and ketones into 1,3-dicarbonyl compounds

Abstract A novel and mild protocol for the hydration of electron-deficient allenic esters and ketones into various 1,3-dicarbonyl compounds is described. The hydration of allenes promoted by oxone in DMF afforded the corresponding products in moderate to good yields. This work features the employment of only a catalytic amount of inexpensive and nontoxic solid reagent oxone (2KHSO5·KHSO4·K2SO4), avoiding the utility of toxic metals or traditional Br?nsted acids, in a green version of viewpoint. A possible reaction mechanism for this transformation is also primarily proposed.

A general synthesis of dioxolenone prodrug moieties

A general method for the synthesis of dioxolenone prodrug moieties from appropriately substituted β-ketoesters is described. This novel and versatile sequence allows for the synthesis of alkyl- or aryl-substituted dioxolenone alcohols 8 or bromides 9. Coupling of the bromides 9 to prepare bis-dioxolenone phosphonate prodrug esters is also presented.