66698-66-6

Usage

Uses

Used in Pharmaceutical Industry:
6-(TERT-BUTYL)-2-THIOXO-2,3-DIHYDRO-4(1H)-PYRIMIDINONE is used as a building block for the synthesis of pharmaceutical compounds due to its unique structural properties and functional groups. Its presence in the molecular structure can potentially enhance the pharmacological activity and therapeutic efficacy of the resulting compounds.
Used in Chemical Industry:
6-(TERT-BUTYL)-2-THIOXO-2,3-DIHYDRO-4(1H)-PYRIMIDINONE is used as a precursor in the synthesis of various organic compounds. Its structural properties and functional groups make it a versatile component in the development of new chemical entities with potential applications in different fields.
The properties and potential uses of 6-(TERT-BUTYL)-2-THIOXO-2,3-DIHYDRO-4(1H)-PYRIMIDINONE can be further studied and explored by researchers in the field to unlock its full potential in various applications.

InChI:InChI=1/C8H12N2OS/c1-8(2,3)5-4-6(11)10-7(12)9-5/h4H,1-3H3,(H2,9,10,11,12)

Upstream product

• 17094-34-7 ethyl pivaloylacetate 
• 17356-08-0 thiourea 
• 55107-14-7 Methyl 4,4-dimethyl-3-oxopentanoate 

Downstream Products

• 1376685-37-8 5-{[(4-tert-butyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide 
• 1376685-70-9 4-{[(4-tert-butyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide 
• 3438-49-1 4-hydroxy-6-tert-butylpyrimidine 

Relevant academic research and scientific papers

Complexes of palladium(II) and platinum(II) with 6-tert-butyl-2-thiouracil

cis-Dihalogeno complexes of platinum(II) and palladium(II) with 6-tert-butyl-2-thiouracil have been synthesized. The mode of coordination of the ligand to metal ions was established by IR and NMR spectroscopy.

Laccase-catalyzed green synthesis and cytotoxic activity of novel pyrimidobenzothiazoles and catechol thioethers

The laccase-catalyzed reaction between unsubstituted catechol and 2-thioxopyrimidin-4(1H)-ones using aerial O2 as the oxidant delivers novel pyrimidobenzothiazoles with high yields in an aqueous solvent system under mild reaction conditions. With 4-substituted catechols, catechol thioethers are formed exclusively. The synthetic protocols developed provide a sustainable approach for these compound classes. In addition, the cytotoxicity of the products against HepG2 cell line is reported. Most compounds exhibit antiproliferative activities with IC50 values at the micromolar level. A structure-activity relationship study will facilitate the further development of these compounds as cytotoxic agents.

Microwave-assisted synthesis of substituted: 2-(benzylthio)imidazo[1,2a] pyrimidin-5-ones

A microwave-assisted solid-phase synthesis of 2-(benzylthio)imidazo[1,2a] pyrimidin-5-ones has been developed. Using microwave irradiation, the reaction time was significantly reduced from a few days to 80 min. A representative set of 10 2-(benzylthio)-6,7-substituted-imidazo[1,2a]pyrimidin-5-ones was prepared. These compounds were subsequently N-alkylated and formylated in good yields.