667-71-0Relevant academic research and scientific papers
Wrightiamines A and B, two new cytotoxic pregnane alkaloids from Wrightia javanica
Kawamoto, Souichi,Koyano, Takashi,Kowithayakorn, Thaworn,Fujimoto, Haruhiro,Okuyama, Emi,Hayashi, Masahiko,Komiyama, Kanki,Ishibashi, Masami
, p. 737 - 739 (2007/10/03)
Two new pregnane alkaloids, wrightiamines A (1) and B (2), were isolated from the extract of the tropical Apocynaceous plant Wrightia javanica collected in Thailand, and their structures were elucidated by spectral data. Wrightiamine B (2) was preparaed from 3β-hydroxy-5α-pregnan-20-one to establish the configuration of the C-20 position as S. Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.
AMINO STEROIDS - PHYSICOCHEMICAL BEHAVIOUR AND CONFORMATION OF EPIMERIC 20-AMINOPREGNANES AN INTERPRETATION BASED ON 1H AND 13C NMR DATA
Biesemans, M.,Woude, G. Van de,Hove, L. van
, p. 59 - 68 (2007/10/02)
The marked inversion of properties such as polarity and basicity observed within a couple of epimeric 20-aminopregnanes carrying an ethylene acetal function at 12, compared with the corresponding couples carrying a ketone function at 12 or those lacking substitution at 12, is the result of a hydrogen bond between the acetal and the amine functions as shown by 1H and 13C NMR analyses.
