66726-12-3

Basic information

• Product Name: (3R,3aR,5aS,9bS)-3,5a,9-trimethyl-3-(phenylselanyl)-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione
• CAS NO: 66726-12-3
• Molecular Formula: C₂₁H₂₂O₃Se
• Molecular Weight: 401.3576
• Mol File: 66726-12-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 553.6°C at 760 mmHg
• Flash Point: 288.6°C
• Vapor Pressure: 2.68E-12mmHg at 25°C
• CAS DataBase Reference: (3R,3aR,5aS,9bS)-3,5a,9-trimethyl-3-(phenylselanyl)-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,3aR,5aS,9bS)-3,5a,9-trimethyl-3-(phenylselanyl)-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione(66726-12-3)
• EPA Substance Registry System: (3R,3aR,5aS,9bS)-3,5a,9-trimethyl-3-(phenylselanyl)-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione(66726-12-3)

Safety Data

• Hazardous Substances Data: 66726-12-3(Hazardous Substances Data)

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 481-06-1 santonin 
• 1666-13-3 diphenyl diselenide 

Downstream Products

• 66726-11-2 (3αS,5αS,9βS)-5α,9-dimethyl-3-methylene-3α,5,5α,9β-tetrahydronaphtho[1,2-β]furan-2,8(3H,4H)-dione 

Relevant articles and documents

Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells

Despite notable advances in utilising PARP inhibitor monotherapy, many cancers are not PARP inhibitor-sensitive or develop treatment resistance. In this work, we show that the two structurally-related sesquiterpene lactones, a 2-bromobenzyloxy derivative

Synthesis and biological evaluation of α-santonin derivatives as anti-hepatoma agents

A series of α-santonin-derived compounds as potentially anti-hepatoma agents were designed and synthesized in an effort to find novel therapeutic agents. Among them, derivative 5h was more potent than the positive control 5-fluorouracil (5-Fu) on HepG-2, QGY-7703 and SMMC-7721 with IC50 values of 7.51, 3.06 and 4.08 μM, respectively. The structure-activity relationships (SARs) of these derivatives were discussed. In addition, flow cytometry and western blot assay revealed that the derivatives induced hepatoma cells apoptosis by facilitating apoptosis-related proteins expressions. Our findings suggested that these α-santonin-derived analogues hold promise as chemotherapeutic agents for the treatment of human hepatocellular cancer.

Design, synthesis and anticancer activity of Michael-type thiol adducts of α-santonin analogue with exocyclic methylene

Abstract A series of Michael-type analogues were generated on the C-ring of α-santonin (α-methylene-γ-butyrolactone) upon reaction with various thiols. All the thiol adducts synthesized were evaluated for their anticancer activity against four human cance