66728-83-4Relevant academic research and scientific papers
Selective deprotection of benzyl (Bn) ethers in the presence of para-methoxybenzyl (PMB) ethers
Li, Xiaohua,Saleh, Zachary,Egri, Brian,Hourani, Ali,Harding, Luke,Baryal, Kedar N.,Zhu, Jianglong
, p. 1420 - 1422 (2015/03/04)
Substituted benzyl ethers have been widely used as readily manipulatable protecting groups for organic synthesis. It is known that electron-rich para-methoxybenzyl (PMB) ethers can be selectively deprotected over benzyl or other electron-poor benzyl ethers under oxidative conditions. In this presentation, we will describe an approach for selective deprotection of benzyl ethers in the presence of PMB ethers under reductive conditions. This new method should complement the existing strategies in the utilization of substituted benzyl ethers in organic synthesis, especially in carbohydrate synthesis.
Iron(III)-catalyzed prins cyclization towards the synthesis of trans-Fused bicyclic tetrahydropyrans
Pérez, Sixto J.,Miranda, Pedro O.,Cruz, Daniel A.,Fernández, Israel,Martín, Víctor S.,Padrón, Juan I.
, p. 1791 - 1798 (2015/06/16)
trans-Fused bicyclic tetrahydropyrans have been synthesized through an intramolecular Prins cyclization catalyzed by iron(III). The cyclization process is stereoselective, leading exclusively to an all-cis configuration in the newly generated ring. This u
Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: Synthesis and antiviral studies
Bereczki, Ilona,Kicsák, Máté,Dobray, Laura,Borbás, Anikó,Batta, Gyula,Kéki, Sándor,Nikodém, éva Nemes,Ostorházi, Eszter,Rozgonyi, Ferenc,Vanderlinden, Evelien,Naesens, Lieve,Herczegh, Pál
, p. 3251 - 3254 (2014/07/22)
In order to obtain new, cluster-forming antibiotic compounds, teicoplanin pseudoaglycone derivatives containing two lipophilic n-octyl chains have been synthesized. The compounds proved to be poor antibacterials, but, surprisingly, they exhibited potent anti-influenza virus activity against influenza A strains. This antiviral action was related to inhibition of the binding interaction between the virus and the host cell. Related analogs bearing methyl substituents in lieu of the octyl chains, displayed no anti-influenza virus activity. Hence, an interaction between the active, dually n-octylated compounds and the lipid bilayer of the host cell can be postulated, to explain the observed inhibition of influenza virus attachment.
