667403-90-9

Basic information

• Product Name: 5-bromo-2-[(4-chlorobenzoyl)amino]benzoic acid
• Synonyms: 5-Bromo-2-[(4-chlorobenzoyl)amino]benzoic acid; benzoic acid, 5-bromo-2-[(4-chlorobenzoyl)amino]-
• CAS NO: 667403-90-9
• Molecular Formula: C₁₄H₉BrClNO₃
• Molecular Weight: 354.5832
• Mol File: 667403-90-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 417.1°C at 760 mmHg
• Flash Point: 206.1°C
• Density: 1.696g/cm³
• Vapor Pressure: 1.05E-07mmHg at 25°C
• Refractive Index: 1.695
• CAS DataBase Reference: 5-bromo-2-[(4-chlorobenzoyl)amino]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-[(4-chlorobenzoyl)amino]benzoic acid(667403-90-9)
• EPA Substance Registry System: 5-bromo-2-[(4-chlorobenzoyl)amino]benzoic acid(667403-90-9)

Safety Data

• Hazardous Substances Data: 667403-90-9(Hazardous Substances Data)

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 74-11-3 para-chlorobenzoic acid 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 118-92-3 anthranilic acid 

Downstream Products

• 198819-46-4 6-bromo-2-(4-chloro-phenyl)-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens

Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate(B) as best hits with allosteric mode of inhibition. FabG is an integral part of bacterial fatty acid biosynthetic system FAS II shown to be an essential gene in most ESKAPE Pathogens. The current work is focussed on lead expansion of these two hit molecules which ended up with forty-three analogues (twenty-nine analogues from lead compound A and fourteen compounds from lead compound B). The enzyme inhibition studies revealed that compound 15 (effective against EcFabG, AbFabG, StFabG, MtFabG1) and 19 (inhibiting EcFabG and StFabG) had potency of broad-spectrum inhibition on FabG panel.

Synthesis and biological activity of N-acyl-5-bromanthranilic acids

Ten N-acyl-5-bromanthranilic acids have been obtained via acylation of 5-bromanthranilic acid with appropriate anhydrides. The antiinflammatory and antibacterial properties of the synthesized compounds have been evaluated. It is established that N-(o-anisoyl)-5-bromanthranilic acid possesses most pronounced antiinflammatory activity (49% inhibition of carrageenan induced paw edema in rat) and antimicrobial properties (MIC = 2.0 μg/ml with respect to St. aureus and E. coli).