667462-90-0

Usage

Core Structure

1,2,4-Triazine

Functional Group

3,5(2H,4H)-dione

Side Chain

4-amino-6-[2-(2-hydroxy-1-naphthalenyl)ethenyl]

Additional Moiety

3-[(2,4-dinitrophenyl)hydrazone]

Potential Applications

Pharmaceuticals, Agrochemicals, Materials Science

Unique Features

Complex structure with varied functional groups

Possible Studies

Biological and Chemical Properties

Upstream product

• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 
• 352295-92-2 4-amino-6-[2-(2-hydroxy-naphthalen-1-yl)-vinyl]-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one 

Relevant academic research and scientific papers

Synthesis of heterobicyclic nitrogen systems bearing a 1,2,4-triazine moiety as anticancer drugs: Part IV

Some new isolated and fused heterobicyclic nitrogen systems such as thiazolidinone, imidazolone, pyrimidinone, quinazolone, as-triazolone, as-triazinones, tetrazino-as-triazines, and the related compounds 3,4-diaminotriazine and sulfa derivatives 2-27 have been synthesized via treatment of 4-amino-6-styryl-3-thioxo-1,2,4-triazin-5(2,4H)ones (1) with cyclic and acyclic oxygen and nitrogen compounds. The structures of the products have been established from their elemental and spectral analyses. Some new compounds exhibited significant anticancer activities, where compounds 11j > 2a > 6 and 11I > 14 > 11k showed a moderate activity toward leukemia, ovarian cancer, and non-small cell lung cancer.