667463-85-6 Usage
Uses
Used in Pharmaceutical Industry:
(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME is used as a potent and selective GSK-3a/b inhibitor for its ability to reduce the invasiveness of gliomas, a type of aggressive brain cancer. Its inhibitory effects on GSK-3 have been shown to extend animal survival in intracranial glioma models, making it a potential therapeutic agent for glioma treatment.
Additionally, (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME is used to induce Wnt signaling, a critical pathway involved in various cellular processes, including cell proliferation, differentiation, and migration. Modulating Wnt signaling can have therapeutic benefits in treating various diseases, including cancer.
Furthermore, (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME is used to inhibit CD8+ T cell effector differentiation, which can be beneficial in the context of autoimmune diseases and transplantation. By inhibiting the differentiation of CD8+ T cells, (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME can potentially help regulate immune responses and improve treatment outcomes in these conditions.
Biological Activity
Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Check Digit Verification of cas no
The CAS Registry Mumber 667463-85-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,7,4,6 and 3 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 667463-85:
(8*6)+(7*6)+(6*7)+(5*4)+(4*6)+(3*3)+(2*8)+(1*5)=206
206 % 10 = 6
So 667463-85-6 is a valid CAS Registry Number.
