667463-85-6

Basic information

• Product Name: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
• Synonyms: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME;BIO-ACETOXIME;GSK-3 INHIBITOR X;(3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one;6-Bromoindirubin acetoxime;6-Bromoindirubin-3′-acetoxime;GSK3 Inhibitor IX2;BIO-acetoxime(GSK-3 Inhibitor)
• CAS NO: 667463-85-6
• Molecular Formula: C18H12BrN3O3
• Molecular Weight: 398.22
• EINECS: 200-258-5
• Product Categories: Other enzyme inhibitors and activators
• Mol File: 667463-85-6.mol
• Article Data: 0

Chemical Properties

• Appearance: , dark red to purple/
• Density: 1.69±0.1 g/cm3(Predicted)
• Storage Temp.: Store at +4°C
• Solubility: H2O: soluble2mg/mL (clear solution, warmed)
• PKA: 9.22±0.20(Predicted)
• CAS DataBase Reference: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME(CAS DataBase Reference)
• NIST Chemistry Reference: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME(667463-85-6)
• EPA Substance Registry System: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME(667463-85-6)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 667463-85-6(Hazardous Substances Data)

Usage

Uses

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Biological Activity

Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.