667466-74-2Relevant academic research and scientific papers
γ-oxo carboxylic acids in heterocyclic synthesis IV. Synthesis of some pyridazines containing phthalyl and tosyl amino acids using DCC as the condensing agent
Aly,Wasfy
, p. 1911 - 1921 (2003)
The 3(2H)-oxo-, 3(2H)-thioxo- or 3-amino-pyridazine derivatives 4, 6 and 7 were coupled with N-phthalyl- or N-tosyl-amino acids in one-step using N,N′-dicyclohexyl-carbodiimide as the condensing agent to furnish the corresponding 3-(N-phthalyl- or N-tosyl-aminoacyl)pyridazine derivatives 8-10 respectively. Hydrazinolysis of the N-phthalyl derivatives in methanol yielded the corresponding unprotected derivatives 11-13. The antibacterial activities of the prepared compounds were tested.
γ-oxo carboxylic acids in heterocyclic synthesis: Part IV - Synthesis of some pyridazines containing phthalyl and tosyl amino acids using DCC as the condensing agent
Aly,Wasfy
, p. 629 - 635 (2007/10/03)
3(2H)-Oxo-, 3-mercapto- or 3-amino-pyridazine derivatives 3,5 and 6 have been coupled with N-phthalyl- or N-tosyl-amino acids in one-step at room temperature by using N,N′-dicyclohexylcarbodiimide as the condensing agent to furnish the corresponding 3-N-(phthalyl- or tosyl-amino acids) pyridazine derivatives (7-9)a-h, respectively. Hydrazinolysis of the N-phthalyl derivatives (7-9)a-d in methanol yields the corresponding unprotected derivatives (7-9)M 9)i-l. The anti-bacterial activity of the prepared compounds has been tested.
