66757-08-2

Upstream product

• 71687-03-1 (2E,4E)-3-methyl-5-phenyl-2,4-pentadien-1-ol 
• 80453-93-6 (2E,4E,6E)-(8R,9S)-8-Hydroxy-3,7-dimethyl-9-phenyl-deca-2,4,6-trienedioic acid 1-ethyl ester 
• 63826-41-5 2E,4E,6E-2,6-Dimethyl-7-ethoxycarbonyl-2,4,6-heptatrienal 
• 103-82-2 phenylacetic acid 
• 80453-89-0 (2E,4E,6E)-(8S,9R)-8-Acetoxy-3,7-dimethyl-9-phenyl-deca-2,4,6-trienedioic acid 1-ethyl ester 

Relevant academic research and scientific papers

A cross-metathesis approach to the synthesis of new etretinate type retinoids, ethyl retinoate and its 9Z-isomer

Two aromatic retinoids were synthesized from styrene derivatives using a novel strategy with a cross-metathesis reaction as a key step. The biological activity of the new etretinate analogues was tested. Cross-metathesis reactions were also employed for the preparation of ethyl retinoate and its 9Z-isomer via the C15 + C5 route.

PALLADIUM CATALYZED FRAGMENTATION REACTION AS AN APPROACH TO VITAMIN A ESTER

A novel C10 + C10 approach to retinoids employing a palladium induced decarboxylative elimination is described.