66761-27-1Relevant articles and documents
Synthesis, characterization and cytotoxic activity evaluation of 4-(1,2,3-triazol-1-yl) salicylic acid derivatives
Barroso-Flores, Joaquín,Cano-Herrera, Ma-Angeles,Cuevas-Ya?ez, Erick,Dávila-Becerril, Juan Carlos,García-Eleno, Marco Antonio,González-Rivas, Nelly,Mondragón-Solórzano, Gustavo,Morales-Morales, David,Ríos-Malváez, Zita G.,Ramírez-Apan, María Teresa,Santillán-Benítez, Jonnathan G.,Unnamatla, M. V. Basavanag
, (2021)
A novel series of 4-(1,2,3-triazol-1-yl) salicylic acid derivatives was synthesized from 4-azidosalicylic acid and diverse alkynes using copper catalyzed azide-alkyne cycloaddition as key process and fully characterized by using different analytical techn
Controlled Supramolecular Assembly Inside Living Cells by Sequential Multistaged Chemical Reactions
Pieszka, Michaela,Han, Shen,Volkmann, Christiane,Graf, Robert,Lieberwirth, Ingo,Landfester, Katharina,Ng, David Y. W.,Weil, Tanja
supporting information, p. 15780 - 15789 (2020/10/18)
Synthetic assembly within living cells represents an innovative way to explore purely chemical tools that can direct and control cellular behavior. We use a simple and modular platform that is broadly accessible and yet incorporates highly intricate molecular recognition, immolative, and rearrangement chemistry. Short bimodular peptide sequences undergo a programmed sequence of events that can be tailored within the living intracellular environment. Each sequential stage of the pathways beginning with the cellular uptake, intracellular transport, and localization imposes distinct structural changes that result in the assembly of fibrillar architectures inside cells. The observation of apoptosis, which is characterized by the binding of Annexin V, demonstrates that programmed cell death can be promoted by the peptide assembly. Higher complexity of the assemblies was also achieved by coassembly of two different sequences, resulting in intrinsically fluorescent architectures. As such, we demonstrate that the in situ construction of architectures within cells will broaden the community's perspective toward how structure formation can impact a living system.
LANTHANIDE CLUSTERS AND METHODS OF USE THEREOF
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Paragraph 0223; 0224, (2016/01/30)
The present invention is directed to multinuclear lanthanides chiral clusters, based on phenyl-oxazoline-amide (POxA) ligands, and to methods of use thereof. The chiral clusters of this invention are highly fluorescent with high stability.